Elevated CCR5 would be so easy. But just because there's elevated CCR5 doesn't necessarily mean blocking it will be an effective treatment. It's necessary to understand the disease first. What I do is go through medical papers on that disease and figure out what the causation is working backwards through which pathways are fundamental to the disease. I look at a lot of specific papers relating to CCR5 and the disease. I then look at the specific known activities of leronlimab and its ability to stop the causation.

It seems fairly straightforward but it isn't. For example in COVID-19 - I had a pretty good idea from past research in cancer that leronlimab might have an effect on GM-CSF. I had to read through about 30-40 papers and string together research from 5 of them to figure out the pathway between CCR5 blockade and downregulation of GM-CSF.

The best thing I have on my side is a dogged determination to find something out when I set my mind to it and a decent logical mindset.