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Posted On: 09/06/2020 12:35:44 AM
Post# of 155519
Re: Riztheinvestor #54384
Ritz,
Leronlimab may absolutely help even in advanced TNBC. Remember that blocking CCR5 not only reduces metastasis but reduces the ability of tumor cells to maintain the micro-environment that enables them to avoid other chemotherapies and the body's immune system.
Here is a recent article (Oct 2019):
Recent Advances Targeting CCR5 for Cancer and Its Role in Immuno-Oncology/
https://cancerres.aacrjournals.org/content/79...1-tag-here
It is quite dense, but the important section of the abstract states:
"The misexpression of CCR5 in epithelial cells, induced upon oncogenic transformation, hijacks this migratory phenotype [Regulatory T-Cells]. CCR5 reexpression augments resistance to DNA-damaging agents and is sufficient to induce cancer metastasis.
Leronlimab may absolutely help even in advanced TNBC. Remember that blocking CCR5 not only reduces metastasis but reduces the ability of tumor cells to maintain the micro-environment that enables them to avoid other chemotherapies and the body's immune system.
Here is a recent article (Oct 2019):
Recent Advances Targeting CCR5 for Cancer and Its Role in Immuno-Oncology/
https://cancerres.aacrjournals.org/content/79...1-tag-here
It is quite dense, but the important section of the abstract states:
"The misexpression of CCR5 in epithelial cells, induced upon oncogenic transformation, hijacks this migratory phenotype [Regulatory T-Cells]. CCR5 reexpression augments resistance to DNA-damaging agents and is sufficient to induce cancer metastasis.
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