Yes, thanks Giacomo27.

Someone early today when posing these questions also asked “if we shrink tumors.”

I would add, as a layman, that we have two MOAs apart from CCR5 inhibition MOA that affect tumors.

Leronlimab halts tumor angiogenesis. The usual tumor tricks the bodies circulation system (Angio) into growing blood vessels (Genesis) supplying oxygenated blood to the tumor for growth purposes. This slows/halts tumor growth. Angiogenesis is particularly important when a Circulating Tumor Cell embeds itself in the soft tissue of a new organ, say if bladder cancer starts taking hold in the brain. If it can’t feed or breath, it can’t grow.

The question about shrinking tumors from earlier today caused me to wonder if Leronlimab’s affect on angiogenesis ‘Reverses’ the blood supply to tumors. My instinct says No, but IDK.

So the above halts tumor growth. The below reduces tumor size IMHO.

Repolarizing of macrophages and regulating the tumor micro environment should halt growth and reduce tumor size. When a macrophage is polarized one way (sorry which way I can’t say) the macrophage supports tumor growth. When the same macrophage is polarized the other way, it ‘consumes’ cancer cells. This should stop metastasis, and I hope decrease tumor size, but once again, IDK.

I hope this helps generally. I know I’m not an expert. But sometimes understanding comes in the ground floor window.

From one layman to another. Experts, please add or correct as needed.

Good day folks. GLTU!