Per the conf call, over expressed CCR5 relates directly to increased cancer risk and under expressed relates directly with positive survival.

Most melanomas kill when they metastasize, my recent surgery/removal of a melanoma was sent to Castle Bio for a trial they are running to determine the genetic likelihood of metastasis. There is only one reason we want to know the odds of it metastasizing. Because most cancers kill the exact same way; a single tumor will not kill most people, multiple tumors is what kills most people.