I sent the following to a college classmate who is an ED Doc. More importantly, her father is/was the head of renal transplantation program in Seattle. Very likely a tad more clout that an a paramedic in an impoverished city in CT.
H*****.
I hope you remain well. I see you are practicing in WA state. I remain a Paramedic in CT. I don’t know if you are aware, but a small biotech company in Vancouver, WA has developed a CCR5 receptor occupying mAb that is a potent therapeutic for Covid among other diseases. Investment opportunity for you, but it needs to be known widely to be approved and the disseminated for clinical use.
This is an email I sent to a Washington Post science write (Amherst alumna, but what can you do),
Dear Ms. Johnson,
There are hundreds of vaccines and therapeutics in development for Covid-19, to date none with significant clinical effect. However, Leronlimab is a monoclonal antibody (mAb) with demonstrated efficacy in treating Covid-19 disease and the associated cytokine storm of immune dysregulation. A clinical trial of Leronlimab is complete for the mild/moderate patient population. This trial demonstrated clinical and statistical significance and a request has been submitted to the FDA for Emergency Use Authorization.
Leronlimab blocks the binding site of the CCR5 receptor on macrophages, t-lymphocytes, and eosinophils. This stops chemotaxic trafficking of immune cells to areas of inflammation, halting the inflammatory cascade and the cytokine storm. Furthermore, blocking of CCR5 repolarizes macrophages and reverses exhaustion of CD8 lymphocytes, permitting normal immune function and resumption of antiviral activity through natural killer T-cells and granzyme-A antiviral production.
Former Stanford University Virologist Dr. Bruce Patterson in a manuscript from May 5 titled has described this mechanism of Leronlimab:
Disruption of the CCL5/RANTES-CCR5 Pathway Restores Immune Homeostasis and Reduces Plasma Viral Load in Critical COVID-19
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7277012/
Cytodyn, the maker of Leronlimab has submitted top line data from a double blinded, placebo-controlled study to the FDA for Leronlimab. Leronlimab demonstrates statistically significant improvement in NEWS2 (National Early Warning Score), a widely accepted UK clinical metric for measuring the progression of COVID into the severe/critical phase. (P=0.02). Leronlimab increased the number of patients who showed clinical improvement in the NEWS2 score, by 150%.
Study to Evaluate the Efficacy and Safety of Leronlimab for Mild to Moderate COVID-19
https://clinicaltrials.gov/ct2/show/NCT043436...amp;rank=3
In addition, Leronlimab has demonstrated reduced mortality in the severe/critical population in over 70 EIND patients. A phase 3 trial is ongoing for this population, with an interim analysis of the data due in the coming weeks.
Study to Evaluate the Efficacy and Safety of Leronlimab for Patients With Severe or Critical Coronavirus Disease 2019 (COVID-19)
https://clinicaltrials.gov/ct2/show/NCT043472...amp;rank=4
Cytodyn is a small biotech company, which does not yet have an FDA approval in any indication, so with cessation of EIND authorization Leronlimab is unavailable to patients outside of clinical trial sites.
Please research Cytodyn, and reach out to the company for more information.
www.cytodyn.com
Nader Pourhassan, PhD CEO npourhassan@cytodyn.com
Scott Kelly, MD CMO skelly@Cytodyn.com
I have invested in this. You may choose to as well. You and your colleagues should be aware and, IMO leverage your position as physicians to bring this to market for the good of all of us.
Be well.
S*
H*****.
I hope you remain well. I see you are practicing in WA state. I remain a Paramedic in CT. I don’t know if you are aware, but a small biotech company in Vancouver, WA has developed a CCR5 receptor occupying mAb that is a potent therapeutic for Covid among other diseases. Investment opportunity for you, but it needs to be known widely to be approved and the disseminated for clinical use.
This is an email I sent to a Washington Post science write (Amherst alumna, but what can you do),
Dear Ms. Johnson,
There are hundreds of vaccines and therapeutics in development for Covid-19, to date none with significant clinical effect. However, Leronlimab is a monoclonal antibody (mAb) with demonstrated efficacy in treating Covid-19 disease and the associated cytokine storm of immune dysregulation. A clinical trial of Leronlimab is complete for the mild/moderate patient population. This trial demonstrated clinical and statistical significance and a request has been submitted to the FDA for Emergency Use Authorization.
Leronlimab blocks the binding site of the CCR5 receptor on macrophages, t-lymphocytes, and eosinophils. This stops chemotaxic trafficking of immune cells to areas of inflammation, halting the inflammatory cascade and the cytokine storm. Furthermore, blocking of CCR5 repolarizes macrophages and reverses exhaustion of CD8 lymphocytes, permitting normal immune function and resumption of antiviral activity through natural killer T-cells and granzyme-A antiviral production.
Former Stanford University Virologist Dr. Bruce Patterson in a manuscript from May 5 titled has described this mechanism of Leronlimab:
Disruption of the CCL5/RANTES-CCR5 Pathway Restores Immune Homeostasis and Reduces Plasma Viral Load in Critical COVID-19
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7277012/
Cytodyn, the maker of Leronlimab has submitted top line data from a double blinded, placebo-controlled study to the FDA for Leronlimab. Leronlimab demonstrates statistically significant improvement in NEWS2 (National Early Warning Score), a widely accepted UK clinical metric for measuring the progression of COVID into the severe/critical phase. (P=0.02). Leronlimab increased the number of patients who showed clinical improvement in the NEWS2 score, by 150%.
Study to Evaluate the Efficacy and Safety of Leronlimab for Mild to Moderate COVID-19
https://clinicaltrials.gov/ct2/show/NCT043436...amp;rank=3
In addition, Leronlimab has demonstrated reduced mortality in the severe/critical population in over 70 EIND patients. A phase 3 trial is ongoing for this population, with an interim analysis of the data due in the coming weeks.
Study to Evaluate the Efficacy and Safety of Leronlimab for Patients With Severe or Critical Coronavirus Disease 2019 (COVID-19)
https://clinicaltrials.gov/ct2/show/NCT043472...amp;rank=4
Cytodyn is a small biotech company, which does not yet have an FDA approval in any indication, so with cessation of EIND authorization Leronlimab is unavailable to patients outside of clinical trial sites.
Please research Cytodyn, and reach out to the company for more information.
www.cytodyn.com
Nader Pourhassan, PhD CEO npourhassan@cytodyn.com
Scott Kelly, MD CMO skelly@Cytodyn.com
I have invested in this. You may choose to as well. You and your colleagues should be aware and, IMO leverage your position as physicians to bring this to market for the good of all of us.
Be well.
S*
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