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Posted On: 08/07/2020 9:35:25 PM
Post# of 72440
I made this list from the link below
Remdesivir SI 129.87
Cloroquine SI 88.5
Favipiravir SI 6.46
Penciclovir SI 4.17
Ribavirin SI 3.65
https://www.nature.com/articles/s41422-020-0282-0
Most of us are familiar with Hydroxychloroquine and Remdesivir. Favipiravir was developed in Japan and is approved in a number of countries as a Covid 19 drug.
Selectivity Index= 50% cytotoxic index/50%effective index
cytotoxic index-dose of drug to damage 50% of {human epithelial lung cells from last PR ]cells
effective index-the dose of drug to produce 50% viral death
A High SI would need a high dose to reach a toxic level and a low dose to kill viruses
From the last PR:
"RBL scientists next plan to determine, in human lung cells, Brilacidin’s Selectivity Index—a ratio determined from in vitro data that compares a drug’s cytotoxicity and antiviral activity. The higher the SI ratio, the more effective and safe a drug has the potential to be in the clinic. These data will help to inform Brilacidin’s inhibitory properties against the novel coronavirus, and allow comparison to other treatments, all to be detailed in a planned peer-review publication."
http://www.ipharminc.com/press-release/2020/7...ical-trial
Brilacidin's SI with in vitro testing against Covid19 would allow it to be compared to our anti viral Covid19 competitors SI from previous in vitro testing.
So what is Brilacidin's SI?
"Brilacidin exhibited a statistically significant (p<0.0001) and potent inhibitory effect on SARS-CoV-2, the novel coronavirus responsible for COVID-19, in a human lung epithelial cell line—reducing viral load by 95 percent and by 97 percent, compared to control, at two therapeutic concentrations tested. Based on a CC50 value—the concentration of drug at which 50 percent of cells maintain viability—Brilacidin was also shown to be non-cytotoxic in the lung cell line.
http://www.ipharminc.com/press-release/2020/6...-cell-line
So what is Brilacidin's SI? We should know the exact figure soon.
My inference from the report above is it sounds as if is very good. From the PR above it sound like a high dose to produce toxicity and a low dose to produce viral death and the RBL lab researchers will announce the figure soon.
JMO
Good luck to all,Farrell
Remdesivir SI 129.87
Cloroquine SI 88.5
Favipiravir SI 6.46
Penciclovir SI 4.17
Ribavirin SI 3.65
https://www.nature.com/articles/s41422-020-0282-0
Most of us are familiar with Hydroxychloroquine and Remdesivir. Favipiravir was developed in Japan and is approved in a number of countries as a Covid 19 drug.
Selectivity Index= 50% cytotoxic index/50%effective index
cytotoxic index-dose of drug to damage 50% of {human epithelial lung cells from last PR ]cells
effective index-the dose of drug to produce 50% viral death
A High SI would need a high dose to reach a toxic level and a low dose to kill viruses
From the last PR:
"RBL scientists next plan to determine, in human lung cells, Brilacidin’s Selectivity Index—a ratio determined from in vitro data that compares a drug’s cytotoxicity and antiviral activity. The higher the SI ratio, the more effective and safe a drug has the potential to be in the clinic. These data will help to inform Brilacidin’s inhibitory properties against the novel coronavirus, and allow comparison to other treatments, all to be detailed in a planned peer-review publication."
http://www.ipharminc.com/press-release/2020/7...ical-trial
Brilacidin's SI with in vitro testing against Covid19 would allow it to be compared to our anti viral Covid19 competitors SI from previous in vitro testing.
So what is Brilacidin's SI?
"Brilacidin exhibited a statistically significant (p<0.0001) and potent inhibitory effect on SARS-CoV-2, the novel coronavirus responsible for COVID-19, in a human lung epithelial cell line—reducing viral load by 95 percent and by 97 percent, compared to control, at two therapeutic concentrations tested. Based on a CC50 value—the concentration of drug at which 50 percent of cells maintain viability—Brilacidin was also shown to be non-cytotoxic in the lung cell line.
http://www.ipharminc.com/press-release/2020/6...-cell-line
So what is Brilacidin's SI? We should know the exact figure soon.
My inference from the report above is it sounds as if is very good. From the PR above it sound like a high dose to produce toxicity and a low dose to produce viral death and the RBL lab researchers will announce the figure soon.
JMO
Good luck to all,Farrell
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