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Posted On: 08/04/2020 10:40:25 PM
Post# of 148936
Re: chessmaster #47133
Very interesting - nanoparticle formulation of leronlimab to make it last longer?
Great idea.
I always wondered when we would be getting DNA or mRNA encoded antibodies too. Much easier to produce, and last a very long time since the patient's own body produces them based on genetic code that sticks around for a while. Here are two platform companies with nucletotide encoded antibodies (INO and MRNA) used for anti-Chikungunya virus antibodies:
https://academic.oup.com/jid/article/214/3/369/2577330
https://immunology.sciencemag.org/content/4/35/eaaw6647
I wonder if it would be worth a collaboration to have long(er) lasting DNA or mRNA encoded leronlimab antibody delivery.
Meh, first things first. Let's get HIV (and Covid if data are good) across the finish line first.
Great idea.
I always wondered when we would be getting DNA or mRNA encoded antibodies too. Much easier to produce, and last a very long time since the patient's own body produces them based on genetic code that sticks around for a while. Here are two platform companies with nucletotide encoded antibodies (INO and MRNA) used for anti-Chikungunya virus antibodies:
https://academic.oup.com/jid/article/214/3/369/2577330
https://immunology.sciencemag.org/content/4/35/eaaw6647
I wonder if it would be worth a collaboration to have long(er) lasting DNA or mRNA encoded leronlimab antibody delivery.
Meh, first things first. Let's get HIV (and Covid if data are good) across the finish line first.
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