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CytoDyn Inc CYDY
(Total Views: 655)
Posted On: 07/24/2020 12:51:17 PM
Post# of 154082
Posted By: ohm20
Re: CDiddy #44877
Only a very low level of GM-CSF is beneficial.

Quote:
By contrast, GM-CSF is barely detectable in the blood of healthy individuals and is thought to serve less of a role in homeostatic myelopoiesis, as evidenced by the fact that GM-CSF-deficient mice have a virtually normal lifespan and have less dramatic alterations in the basal myeloid system,

Importantly, however, GM-CSF is known to be a critical homeostatic factor in lung alveoli, where it is produced at low levels for the development and long-term maintenance of alveolar macrophages. Severe deficiency of GM-CSF (for example, due to autoantibodies to GM-CSF or mutations that ablate GM-CSFR function) causes pulmonary alveolar proteinosis (PAP), a life-threatening interstitial lung disease in which dysfunctional alveolar macrophages cannot clear surfactant


https://www.nature.com/articles/s41577-020-0357-7













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