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Posted On: 07/22/2020 8:06:48 AM
Post# of 148908
Re: Riztheinvestor #44432
Not entirely useless. After listening to that it got me wondering (yes I wonder a lot) why nucleotide RNA polymerase inhibitors like remdesivir and galidesivir might possibly fail. I ran across an interesting article that showed that remdesivir worked only when there was a low level of adenosine triphosphate (ATP). High ATP levels increase viral reproduction.
https://science.sciencemag.org/content/368/6498/1499
From researching CCR5 and cancer I knew that high ATP levels also encourage cancer cell reproduction. High CCR5 levels upregulate ATP. CCR5 blockade drops ATP levels and would be another mechanism to control COVID-19 viral reproduction. I wonder if Dr. Patterson has come to the same conclusion already.
Quote:
Even in the presence of 10 mM ATP, which is within the range of physiological concentrations of ATP, 1 mM RTP completely inhibited RdRp polymerization activity. In addition, 100 µM RTP completely blocked the full extension but allowed partial extension of the primer RNA (Fig. 1D), consistent with a delayed chain termination mechanism (24). However, this mechanism is dependent on low RTP concentrations and low RTP/ATP ratios.
https://science.sciencemag.org/content/368/6498/1499
From researching CCR5 and cancer I knew that high ATP levels also encourage cancer cell reproduction. High CCR5 levels upregulate ATP. CCR5 blockade drops ATP levels and would be another mechanism to control COVID-19 viral reproduction. I wonder if Dr. Patterson has come to the same conclusion already.
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