People of Northern India not only showed resistance to the black death in the 1300's the mutation has thought to have started. The ancestry pf northern vs southern India. The caste system concentrated the gene pool and now mortality is very different between the groups, both dark. This is actually being studied.

In terms of BMT, the target would be the stem cells with a benign viral vector to perform genomic surgery. That is how this receptor was discovered a person with AIDS developed NHL and was cured after his BMT, the donor later was found to have the delta 32 mutation.