If someone is on combo therapy with leronlimab they are likely resistant to one or more of the less expensive first line drugs. Their health care provider will be pretty adamant that they need to be adherent to their medications - or treatment failure could get worse. This population generally doesn’t mess around with their meds.

A few years ago there were studies that looked at taking HIV medications five days in a row and two off. I think it was the FOTO trial. The results were actually pretty good. That schedule would have saved money and reduced some of the side effects- but that treatment schedule didn’t get traction. Again, most providers and patients don’t screw with their meds - the cost of failure isn’t worth it.