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Posted On: 07/03/2020 7:02:34 PM
Post# of 148936
OFF TOPIC flowmax alternative...based on more than a few PM's it looks like I have opened a can of worms, lol, on the side benefits (increased flow) of an all natural kidney stone breaker called Chanca Piedra. It is a plant called Phyllanthus niruri. I found it in an odd late night study on Alzheimers/dementia for my father in-law. I reverse searched the active ingredient in a study I read and found the plant, ta da. Once we got the stuff I decided to try it myself and see if it may help the occasional fog of war from 51 years of harpooning my a$$ with an insulin syringe. I fish, hunt, work hard and function just fine (ask my wife) but I am laying bare my soul here so be kind, ha! Any way, the following are a few interesting articles on the various aspects of the Phyllanthus plants (700 of them), demensia/Alzheimers being one, Quercetin for covid is a big one too.
https://pubmed.ncbi.nlm.nih.gov/24868872/
Isocorilagin, a Cholinesterase Inhibitor From Phyllanthus Niruri
Yee-Hui Koay, Alireza Basiri, Vikneswaran Murugaiyah, Kit-Lam Chan
PMID: 24868872
Abstract
Drugs that have dual inhibition of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) produce better clinical efficacy against Alzheimer's disease (AD) than those that selectively inhibit one enzyme. A dual cholinesterase inhibitory-guided fractionation of Phyllanthus niruri leaves afforded isocorilagin, a bioactive tannin possessing good inhibitory activities against AChE (IC50: 0.49 microM) and BChE (IC50: 4.20 microM). Interestingly, isocorilagin was relatively 2- to 3-fold more potent than galanthamine, the clinically used inhibitor. The kinetic analyses suggested that isocorilagin was a non-competitive inhibitor for AChE and an uncompetitive inhibitor for BChE, with calculated Ki values of 1.49 microM and 2.86 microM, respectively. In silico molecular docking revealed that isocorilagin effectively blocked the substrate entry by forming hydrogen bonding with residues at the entrance of the AChE active site. With BChE, the compound completely docked inside and occupied the active site of the enzyme. This study demonstrated for the first time the potent cholinesterase inhibitory activities of isocorilagin, a promising lead that is worthy of further investigation.
Chemical Components and Biological Activities of the Genus Phyllanthus: A Review of the Recent Literature
Medicinal plants have served humans since prehistoric times to treat various ailments. Both developed and underdeveloped countries rely on traditional systems of medication using natural sources from plants. Phyllanthus is one of the largest genus in the family Phyllanthaceae, comprising over 700 well known species cosmopolitan in distribution mainly in the tropics and subtropics. Phyllanthus species are being in constant used in traditional medications to cure an array of human diseases..and now are being used in practical clinical trials
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222918/
https://pubmed.ncbi.nlm.nih.gov/24868872/
Isocorilagin, a Cholinesterase Inhibitor From Phyllanthus Niruri
Yee-Hui Koay, Alireza Basiri, Vikneswaran Murugaiyah, Kit-Lam Chan
PMID: 24868872
Abstract
Drugs that have dual inhibition of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) produce better clinical efficacy against Alzheimer's disease (AD) than those that selectively inhibit one enzyme. A dual cholinesterase inhibitory-guided fractionation of Phyllanthus niruri leaves afforded isocorilagin, a bioactive tannin possessing good inhibitory activities against AChE (IC50: 0.49 microM) and BChE (IC50: 4.20 microM). Interestingly, isocorilagin was relatively 2- to 3-fold more potent than galanthamine, the clinically used inhibitor. The kinetic analyses suggested that isocorilagin was a non-competitive inhibitor for AChE and an uncompetitive inhibitor for BChE, with calculated Ki values of 1.49 microM and 2.86 microM, respectively. In silico molecular docking revealed that isocorilagin effectively blocked the substrate entry by forming hydrogen bonding with residues at the entrance of the AChE active site. With BChE, the compound completely docked inside and occupied the active site of the enzyme. This study demonstrated for the first time the potent cholinesterase inhibitory activities of isocorilagin, a promising lead that is worthy of further investigation.
Chemical Components and Biological Activities of the Genus Phyllanthus: A Review of the Recent Literature
Medicinal plants have served humans since prehistoric times to treat various ailments. Both developed and underdeveloped countries rely on traditional systems of medication using natural sources from plants. Phyllanthus is one of the largest genus in the family Phyllanthaceae, comprising over 700 well known species cosmopolitan in distribution mainly in the tropics and subtropics. Phyllanthus species are being in constant used in traditional medications to cure an array of human diseases..and now are being used in practical clinical trials
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222918/
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