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Posted On: 06/27/2020 9:43:54 AM
Post# of 148870
This would suggest that CCR1 would play a lesser role than CCR5 in the damage caused by COVID-19. CCR1 does not express on lung macrophages.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2099427/
Quote:
While peripheral blood monocytes expressed the CCL3 receptor, CCR1, alveolar macrophages expressed the alternate CCL3 receptor, CCR5. The addition of anti-CCR5 blocking antibodies completely abrogated CCL3-induced migration in alveolar macrophages, but did not affect the migration of peripheral blood monocytes.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2099427/
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