One of the characteristics that makes Brilacidin so appealing for use in OM and IBD indications is that there is very little systemic absorption anywhere along the digestive tract. That means no side effects for those indications even with substantial dosages.

For COVID? Probably not a pill due to the above.

As the evidence mounts that COVID19 is really a vascular disease, the IV treatment becomes all the more promising. When you have a vascular disease, both as infection and inflammation, a direct infusion makes the most sense.

There was talk of aerosol treatments where previous defensin vs MERS in that form were promising. As the evidence of this being a vascular disease rises I would expect IV to remain the best option. Now, for potential COPD and Asthma indications aerosol may be a great option.

I don't think there is much data on how this would work with a subcutaneous (under the skin) or intramuscular injection (shot in the arm or leg). There are some antibiotics given intramuscularly so maybe it would work.

Still, assuming we're using the single dose that worked in ABSSSI, a simple infusion is almost as easy as an injection. Since you would only get one, and it would prevent hospitalization, I don't see it as any real barrier.

Very exciting.

Go IPIX!
MIGA!