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Posted On: 06/19/2020 2:12:37 PM
Post# of 149158
Re: reallypeople? #38265
This is correspondence from the Montefiore IND docs to the NEJM.
Excerpt:
Although effective treatment of Covid-19 is currently unknown,2 immunosuppressive management included withdrawal of an antimetabolite in 24 of 28 patients (86%). In addition, tacrolimus was withheld in 6 of the 28 severely ill patients (21%). Hydroxychloroquine was administered to 24 of these 28 patients (86%). Apixaban was administered to patients with d-dimer levels higher than 3.0 μg per milliliter. Six severely ill patients received the CCR5 inhibitor leronlimab (PRO 140, CytoDyn) on a compassionate-use basis, and 2 received the interleukin-6 receptor antagonist tocilizumab. Interleukin-6 levels were very elevated (range, 83 to 8175 pg per milliliter) when leronlimab was initiated (on day 0) in the 5 patients with elevated interleukin-6 levels; these levels decreased markedly 3 days later (range, 37 to 2022 pg per milliliter) (see Table S2 in the Supplementary Appendix)
Excerpt:
Although effective treatment of Covid-19 is currently unknown,2 immunosuppressive management included withdrawal of an antimetabolite in 24 of 28 patients (86%). In addition, tacrolimus was withheld in 6 of the 28 severely ill patients (21%). Hydroxychloroquine was administered to 24 of these 28 patients (86%). Apixaban was administered to patients with d-dimer levels higher than 3.0 μg per milliliter. Six severely ill patients received the CCR5 inhibitor leronlimab (PRO 140, CytoDyn) on a compassionate-use basis, and 2 received the interleukin-6 receptor antagonist tocilizumab. Interleukin-6 levels were very elevated (range, 83 to 8175 pg per milliliter) when leronlimab was initiated (on day 0) in the 5 patients with elevated interleukin-6 levels; these levels decreased markedly 3 days later (range, 37 to 2022 pg per milliliter) (see Table S2 in the Supplementary Appendix)
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