From IHUB’s falconer66a,
Fletch
falconer66a Thursday, 06/04/20 02:41:21 PM
Re: None 0
Post # of 253611
Hope this is acceptable:
The superiority of Anavex against the other Alzheimer's treatments needs to be understood.
Ok, a new candidate drug is going to solve the Alzheimer’s problem, not by focusing on amyloid plaques or tau tangles, but by, somehow, improving the function of synapses (contact points between neurons).
Parties “are backing a drug — NDX-1017 — that bypasses the whole toxic plaque debate and focuses on another familiar strategy: the frayed synaptic network in the brain that erodes with the disease. Boost the network and you can stop, possibly reverse, the damage that corrodes cognition. For awhile.”
Well and good — if positive results appear with this new drug. But since the drug in no way addresses root causes of Alzheimer’s, which is the pathogenic non-clearance of wastes in neurons and nerves (the amyloid and tau proteins) those will continue to accumulate.
Understand, all sorts of potentially toxic wastes are continually produced by living cells, tissues, and organisms. Think not? Then don’t use a toilet for 24 hours; see how that works out.
This is where the mechanisms of action (MOA) of the Anavex sigma-1 receptor agonists separate themselves from all the other Alzheimer’s treatment approaches. Each of them (there are but a few), as with this new proposed drug, try to reduce only symptoms. For a period, this, to a degree, can happen. But sooner or later (usually sooner) the biochemical mechanisms of symptomatic suppression are overwhelmed. Fatal.
The real problem is the inability of neurons and nerves with Alzheimer’s to efficiently clear the biochemical wastes, before they can pathogenically accumulate. Here’s an analogy.
Your furnace, in winter, produces toxic waste gases, including carbon dioxide and carbon monoxide. Your furnace, normally and properly, voids these wastes out of the chimney. Well and good.
But how do you “treat” your furnace if a carbon monoxide sensor in your hallway goes off? “Whoa, something’s wrong.” Carbon monoxide is both odorless and fatal (in high concentrations). So, you turn off your furnace, and call the HVAC contractor to fix the problem.
But you could have dealt with it like the current Alzheimer’s drugs do. Treat the symptoms, not the causes of them. Very simple. Just open the windows to allow enough fresh air into the room so as to sufficiently dilute the carbon monoxide. That would work, would it not? Well, until it got really cold.
The solution to both problems, Alzheimer’s and a furnace leaking carbon monoxide into the heating airstreams of a house, is to fix the root cause. In the case of the furnace, find the corroded gap in the fire chamber, and replace it with a new one (or, an entire new furnace). Problem solved.
In the case of Alzheimer’s, biochemically arrange for the restoration of the normalized clearance of wastes. With that, Alzheimer’s is impossible. No pathological accumulation of wastes; neither beta-amyloids or tau tangles. Nerves function normally.
How, then, is this arranged? But ingesting (orally) small amounts of blarcamesine, AKA Anavex 2-73. By its activation of the sigma-1 receptor protein (among other things) this proprietary molecule allows the cell to resume normalized function. “Homeostasis” (feedback-controlled cell processes) is restored. Wastes cannot accumulate. Before they do, their increasing concentration is detected by the cell which, then, turns on increased waste-clearance processes (the cell uses the toilet frequently, as it were).
Essential to all homeostatic processes (and many others) in the cell (especially with age) is the proper folding of proteins into fully functioning enzymes. Blarcamesine causes this. With that, wastes can be enzymatically rendered and compartmentalized into waste-clearing structures before they are pathogenic. Problem solved.
Anavex solves the Alzheimer’s problem at the top, at the start of the cascade of processes that result in the disease. All of the other treatment approaches deal, ever so inadequately or briefly, with only “downstream” factors. The problems continue.
Anavex is way better.
https://investorshub.advfn.com/boards/read_ms...=156058332
Fletch
falconer66a Thursday, 06/04/20 02:41:21 PM
Re: None 0
Post # of 253611
Hope this is acceptable:
The superiority of Anavex against the other Alzheimer's treatments needs to be understood.
Ok, a new candidate drug is going to solve the Alzheimer’s problem, not by focusing on amyloid plaques or tau tangles, but by, somehow, improving the function of synapses (contact points between neurons).
Parties “are backing a drug — NDX-1017 — that bypasses the whole toxic plaque debate and focuses on another familiar strategy: the frayed synaptic network in the brain that erodes with the disease. Boost the network and you can stop, possibly reverse, the damage that corrodes cognition. For awhile.”
Well and good — if positive results appear with this new drug. But since the drug in no way addresses root causes of Alzheimer’s, which is the pathogenic non-clearance of wastes in neurons and nerves (the amyloid and tau proteins) those will continue to accumulate.
Understand, all sorts of potentially toxic wastes are continually produced by living cells, tissues, and organisms. Think not? Then don’t use a toilet for 24 hours; see how that works out.
This is where the mechanisms of action (MOA) of the Anavex sigma-1 receptor agonists separate themselves from all the other Alzheimer’s treatment approaches. Each of them (there are but a few), as with this new proposed drug, try to reduce only symptoms. For a period, this, to a degree, can happen. But sooner or later (usually sooner) the biochemical mechanisms of symptomatic suppression are overwhelmed. Fatal.
The real problem is the inability of neurons and nerves with Alzheimer’s to efficiently clear the biochemical wastes, before they can pathogenically accumulate. Here’s an analogy.
Your furnace, in winter, produces toxic waste gases, including carbon dioxide and carbon monoxide. Your furnace, normally and properly, voids these wastes out of the chimney. Well and good.
But how do you “treat” your furnace if a carbon monoxide sensor in your hallway goes off? “Whoa, something’s wrong.” Carbon monoxide is both odorless and fatal (in high concentrations). So, you turn off your furnace, and call the HVAC contractor to fix the problem.
But you could have dealt with it like the current Alzheimer’s drugs do. Treat the symptoms, not the causes of them. Very simple. Just open the windows to allow enough fresh air into the room so as to sufficiently dilute the carbon monoxide. That would work, would it not? Well, until it got really cold.
The solution to both problems, Alzheimer’s and a furnace leaking carbon monoxide into the heating airstreams of a house, is to fix the root cause. In the case of the furnace, find the corroded gap in the fire chamber, and replace it with a new one (or, an entire new furnace). Problem solved.
In the case of Alzheimer’s, biochemically arrange for the restoration of the normalized clearance of wastes. With that, Alzheimer’s is impossible. No pathological accumulation of wastes; neither beta-amyloids or tau tangles. Nerves function normally.
How, then, is this arranged? But ingesting (orally) small amounts of blarcamesine, AKA Anavex 2-73. By its activation of the sigma-1 receptor protein (among other things) this proprietary molecule allows the cell to resume normalized function. “Homeostasis” (feedback-controlled cell processes) is restored. Wastes cannot accumulate. Before they do, their increasing concentration is detected by the cell which, then, turns on increased waste-clearance processes (the cell uses the toilet frequently, as it were).
Essential to all homeostatic processes (and many others) in the cell (especially with age) is the proper folding of proteins into fully functioning enzymes. Blarcamesine causes this. With that, wastes can be enzymatically rendered and compartmentalized into waste-clearing structures before they are pathogenic. Problem solved.
Anavex solves the Alzheimer’s problem at the top, at the start of the cascade of processes that result in the disease. All of the other treatment approaches deal, ever so inadequately or briefly, with only “downstream” factors. The problems continue.
Anavex is way better.
https://investorshub.advfn.com/boards/read_ms...=156058332
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