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Posted On: 05/31/2020 6:35:00 PM
Post# of 148908
Peacekat, great stuff on RANTES. I found an interesting connection I think may lead to one of the very long lists of potential indications. I hope someone can validate/discredit my thinking/findings here. Some time ago I came across an interesting article tying TGF-β to alzheimers. Here is my progression of connect the dots...
Chemokine CCL5/RANTES is highly expressed in cancer where it contributes to inflammation and malignant progression.... In this study, we show that CCL5 plays a critical role in immune escape in colorectal cancer. .....TGF-β signaling blockade diminished apoptosis of CD8(+) T cells, implicating TGF-β as an effector of CCL5 action. In support of this concept, CCL5 failed to enhance the production of TGF-β by CCR5-deficient T(reg) or to enhance their cytotoxic effects against CD8(+) T cells. CCR5 signaling blockade also diminished the in vivo suppressive capacity of T(reg) in inhibiting the antitumor responses of CD8(+) T cells, in the same way as CCL5 signaling blockade. Together, our findings establish that CCL5/CCR5 signaling recruits T(reg) to tumors and enhances their ability to kill antitumor CD8(+) T cells, thereby defining a novel mechanism of immune escape in colorectal cancer.
https://pubmed.ncbi.nlm.nih.gov/22282655/
Recent data suggest that the TGF-β family of cytokines plays a role in breast cancer stem cells….TGF-β inhibitors have been proposed and are being developed as antimetastatic therapies in patients with cancer.
https://www.jci.org/articles/view/65416
Dr Friedman and Dr Dan Milkovsky - also of Ben-Gurion - used MRI and EEG brain scans to show that the brain leaks triggered brain wave disruptions in animals that mimic those seen in humans with Alzheimer's and other cognitive problems….In their prior research, Drs Friedman and Kaufer had discovered that one particular substance that leaks into the brain effectively poisons a particular receptor there, making a young mouse's brain rapidly turn old and demented.
But if they blocked the receptor, called TGF-β, the blood molecule, albumin, couldn't do anything to the nerves.
https://www.dailymail.co.uk/health/article-77...xkXABL1OVY
Chemokine CCL5/RANTES is highly expressed in cancer where it contributes to inflammation and malignant progression.... In this study, we show that CCL5 plays a critical role in immune escape in colorectal cancer. .....TGF-β signaling blockade diminished apoptosis of CD8(+) T cells, implicating TGF-β as an effector of CCL5 action. In support of this concept, CCL5 failed to enhance the production of TGF-β by CCR5-deficient T(reg) or to enhance their cytotoxic effects against CD8(+) T cells. CCR5 signaling blockade also diminished the in vivo suppressive capacity of T(reg) in inhibiting the antitumor responses of CD8(+) T cells, in the same way as CCL5 signaling blockade. Together, our findings establish that CCL5/CCR5 signaling recruits T(reg) to tumors and enhances their ability to kill antitumor CD8(+) T cells, thereby defining a novel mechanism of immune escape in colorectal cancer.
https://pubmed.ncbi.nlm.nih.gov/22282655/
Recent data suggest that the TGF-β family of cytokines plays a role in breast cancer stem cells….TGF-β inhibitors have been proposed and are being developed as antimetastatic therapies in patients with cancer.
https://www.jci.org/articles/view/65416
Dr Friedman and Dr Dan Milkovsky - also of Ben-Gurion - used MRI and EEG brain scans to show that the brain leaks triggered brain wave disruptions in animals that mimic those seen in humans with Alzheimer's and other cognitive problems….In their prior research, Drs Friedman and Kaufer had discovered that one particular substance that leaks into the brain effectively poisons a particular receptor there, making a young mouse's brain rapidly turn old and demented.
But if they blocked the receptor, called TGF-β, the blood molecule, albumin, couldn't do anything to the nerves.
https://www.dailymail.co.uk/health/article-77...xkXABL1OVY
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