It means using a biomarker as your primary endpoint instead of clinical outcome is pretty lame. Looking at clinical outcomes Kevzara doesn't seem to do very much. I'll let the stat guys figure out the p values but it doesn't look like statistical significance to me.

Side effects should give one pause.

Quote:

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SERIOUS INFECTIONS: KEVZARA is a medicine that affects your immune system. KEVZARA can lower the ability of your immune system to fight infections. Some people have serious infections while using KEVZARA, including tuberculosis (TB), and infections caused by bacteria, fungi, or viruses that can spread throughout the body. Some people have died from these infections.

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