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Posted On: 05/06/2020 7:53:50 AM
Post# of 148899
The dam is coming down.
I love the press release of this morning:
The genie is out of the bottle
On the subject of RANTES and validation of Leronlimab as the anwer to it:
Methods:
Findings:
Interpretations:
Implications of all the available evidence
Is this from DR. Patterson's paper ???
No, the Chinese are "smelling the coffee" and are approaching real fast to the prey ... They have the resources and the science and, not like us, they move fast.
https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3576836
Good thing: We are getting external validation o four Moa, we have the drug, they don't.
Bad Thing: If we don't move (FDA) our bottoms really fast somebody will.
And we had the technology from the onset, safe and effective. What is preventing us from bringing it swiftly to the market ??? I will not answer this question otherwise this post will be (maybe rightfully) deleted.
But ... something is wrong .. Isn' it ???
I love the press release of this morning:
Quote:.
The manuscript has been submitted for publication and is currently under peer review. The pre-print manuscript has also been shared with the World Health Organization
The genie is out of the bottle
On the subject of RANTES and validation of Leronlimab as the anwer to it:
Methods:
Quote:
A total of 71 patients with laboratory-confirmed COVID-19 admitted to Beijing You’an hospital in China with either mild (53 patients) or severe disease (18 patients) were enrolled with 18 healthy volunteers. We measured 34 immune mediators, cytokines and chemokines in peripheral blood every 4-7 days over one month per patient using a bio-plex multiplex immunoassay.
Findings:
Quote:
Findings: We found that the chemokine RANTES(CCL5) was significantly elevated, from an early stage of the infection, in patients with mild but not severe disease. We also found that early production of inhibitory mediators including IL-10 and IL-1RA were significantly associated with disease severity. The majority of cytokines that are known to be associated with the cytokine storm in virus infections such as IL-6 and IFN-gamma were only significantly elevated in the late stage of severe COVID-19 illness. TNF- alpha and GM-CSF showed no significant differences between severe and mild cases.
Interpretations:
Quote:
Together our data strongly suggest a classical cytokine storm may not be the major cause of severe COVID illness. Early intervention to reduce IL-10 and IL-1Ra mediated inhibition or to increase expression of CCL5 may prevent patients from developing severe illness. Our data also suggest that measurement of levels of CCL5, as well as IL-1Ra, IL-10 in blood individually and in combination might be useful prognostic bio-markers to guide treatment strategies.
Implications of all the available evidence
Quote:
Early intervention to reduce IL-10 and IL-1Ra mediated inhibition or to increase expression of CCL5 may prevent patients from developing severe illness; measurement of levels of CCL5, as well as IL-1Ra, IL-10 in blood could provide useful prognostic bio-markers to guide treatment strategies.
Is this from DR. Patterson's paper ???
No, the Chinese are "smelling the coffee" and are approaching real fast to the prey ... They have the resources and the science and, not like us, they move fast.
https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3576836
Good thing: We are getting external validation o four Moa, we have the drug, they don't.
Bad Thing: If we don't move (FDA) our bottoms really fast somebody will.
And we had the technology from the onset, safe and effective. What is preventing us from bringing it swiftly to the market ??? I will not answer this question otherwise this post will be (maybe rightfully) deleted.
But ... something is wrong .. Isn' it ???
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