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Posted On: 05/05/2020 6:14:00 AM
Post# of 72436
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This Bril is one badass juggernaut drug. When it comes to downregulating (i.e., decreasing ) the production of proinflammatory cytokines, it is ALL BEEN LINKED TO its LL37 activity❗LL37 is produced by and secreted by neutrophils, macrophages, and epithelial cells in the respiratory tract AS adaptive innate immune responses triggered by any viral infection! When you increased (or upregulate ) LL37, it turns on, acts, and exhibits its immunomodulatory properties. It even act against the expression of RANTES production (a chemotatic cytokine ) --regulated upon activation of normal T cells. As you all know, RANTES is your CCL5 gene ( with it comes CCR5 receptors --that leronlimab block s! Leronlimab is a CCR5 blocker or inhibitor ). So wow! Go IPIX!!
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