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Posted On: 05/02/2020 11:06:17 AM
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Achilles’ heel of the killer virus: the highly important molecular targets
for hitting SARS‑CoV‑2 that causes COVID‑19
Reza Yousef, · Ali Akbar Moosavi‑Movahedi
Published online: 24 April 2020
© Iranian Chemical Society 2020
Abstract:
The third important molecular targets are the interleukin 6 receptor (IL6R) and
chemokine receptor CCR5. These cytokine receptors can be targeted specifcally by therapeutic antibodies such as Kevzara, Actemra, and Leronlimab or by new under-developing antibodies which subsequently reduce the presence of high levels of infammatory cytokines, within the lungs, known as cytokine storm. In fact, the main cause of death in patients with acute respiratory symptoms is not the virus itself, but the development of an abnormal condition by coronavirus, leading to cytokine molecular storm. Also, with a similar mechanism, infusion of mesenchymal stem cells (MSCs) facilitates patients’ respiratory problems, reducing high level of the infammatory molecules in their lungs.
https://link.springer.com/content/pdf/10.1007...1939-6.pdf
for hitting SARS‑CoV‑2 that causes COVID‑19
Reza Yousef, · Ali Akbar Moosavi‑Movahedi
Published online: 24 April 2020
© Iranian Chemical Society 2020
Abstract:
The third important molecular targets are the interleukin 6 receptor (IL6R) and
chemokine receptor CCR5. These cytokine receptors can be targeted specifcally by therapeutic antibodies such as Kevzara, Actemra, and Leronlimab or by new under-developing antibodies which subsequently reduce the presence of high levels of infammatory cytokines, within the lungs, known as cytokine storm. In fact, the main cause of death in patients with acute respiratory symptoms is not the virus itself, but the development of an abnormal condition by coronavirus, leading to cytokine molecular storm. Also, with a similar mechanism, infusion of mesenchymal stem cells (MSCs) facilitates patients’ respiratory problems, reducing high level of the infammatory molecules in their lungs.
https://link.springer.com/content/pdf/10.1007...1939-6.pdf
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