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Posted On: 04/19/2020 11:45:02 PM
Post# of 72446
I am not an expert on treatment of pulmonary problems with inhaled medications, but I do understand much progress has been made.
The link I posted discussed some of the advances which have been made and will be made in the future. The quote below is from the abstract of the paper. The paper reviews more details of preparation of inhaled pharmaceuticals including peptides for inhalation which of course is of interest if you are considering using Brilacidin as an inhaled medication.
https://www.ncbi.nlm.nih.gov/pubmed/26290195
" Examples of the production of therapeutic {inhaled}
particles for delivery of peptides, antibiotics, anticancer drugs, and the structures of particles obtained with the above mentioned and other methods are presented. The paper concludes with brief information about a recent construction of DPIs for aerosolization of therapeutic particles."
After all many thought it would be impossible to make an inhaler for any peptide much less one much more complex than Brilacidin,but insulin was prepared as a successful treatment for diabetes. An inhaled insulin has been available for some time.
Diabetes Technol Ther. 2018 Oct;20(10):639-647. doi: 10.1089/dia.2018.0200. Epub 2018 Sep 15.
I do not believe your arguments against inhalers will have much influence on scientists seeking improved methods of drug delivery for pulmonary or systemic diseases
https://www.ncbi.nlm.nih.gov/pubmed/28846876
https://www.ncbi.nlm.nih.gov/pubmed/26290195
If IV Brilacidin is effective for treatment of Covid 19 an inhaler will be studied. If an inhaler is developed it will be also studied for a number of pulmonary disorders including asthma, COPD, bronchitis, cystic fibrosis, pulmonary fibrosis and others.
All in my opinion
Good luck,Farrell
The link I posted discussed some of the advances which have been made and will be made in the future. The quote below is from the abstract of the paper. The paper reviews more details of preparation of inhaled pharmaceuticals including peptides for inhalation which of course is of interest if you are considering using Brilacidin as an inhaled medication.
https://www.ncbi.nlm.nih.gov/pubmed/26290195
" Examples of the production of therapeutic {inhaled}
particles for delivery of peptides, antibiotics, anticancer drugs, and the structures of particles obtained with the above mentioned and other methods are presented. The paper concludes with brief information about a recent construction of DPIs for aerosolization of therapeutic particles."
After all many thought it would be impossible to make an inhaler for any peptide much less one much more complex than Brilacidin,but insulin was prepared as a successful treatment for diabetes. An inhaled insulin has been available for some time.
Diabetes Technol Ther. 2018 Oct;20(10):639-647. doi: 10.1089/dia.2018.0200. Epub 2018 Sep 15.
I do not believe your arguments against inhalers will have much influence on scientists seeking improved methods of drug delivery for pulmonary or systemic diseases
https://www.ncbi.nlm.nih.gov/pubmed/28846876
https://www.ncbi.nlm.nih.gov/pubmed/26290195
If IV Brilacidin is effective for treatment of Covid 19 an inhaler will be studied. If an inhaler is developed it will be also studied for a number of pulmonary disorders including asthma, COPD, bronchitis, cystic fibrosis, pulmonary fibrosis and others.
All in my opinion
Good luck,Farrell
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