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Posted On: 04/18/2020 8:00:39 AM
Post# of 154115
After reading the original paper I wonder if the virus uses CD147 and the beta-2 adrenergic receptor (binds β-Arrestin) for invasion like some other infectious agents.
CCL5 (RANTES) recruits β-Arrestin which leads to greater CCR5 expression. β-Arrestin also initiates endocytosis (invasive cell binding).
The increased CCR5 expression would explain the cytokine storm and the endocytosis would explain the ability of COVID-19 to successfully bind to T-cells.
CCL5 (RANTES) recruits β-Arrestin which leads to greater CCR5 expression. β-Arrestin also initiates endocytosis (invasive cell binding).
The increased CCR5 expression would explain the cytokine storm and the endocytosis would explain the ability of COVID-19 to successfully bind to T-cells.
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