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Posted On: 04/07/2020 12:02:21 PM
Post# of 149238
With the new number of patients in a 260:130 trial we have the following binomial distribution of probability:
Which leads to the following linear regression approximation of the required number of successes for the trial to have a p-number less than 0.05:
Minimun number Leronlimab cohort = 1.0706 X number patients survival in placebo cohort + 6.811
Which leads to the following linear regression approximation of the required number of successes for the trial to have a p-number less than 0.05:
Minimun number Leronlimab cohort = 1.0706 X number patients survival in placebo cohort + 6.811
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