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Posted On: 04/04/2020 8:56:38 AM
Post# of 154147
CDiddy,
Great initiative !!!
The best is to explain in lay terms what causes death in COVID patients and why Leronlimab has proven to be very effective.
The Cytokine storm argument is very strong.
Also, it should be related to the measurements that have already demonstrated, a congressman will be more prone to understand that patients have been taken out of ventilators and this does not happen often and that measurements (blood work) confirm that it works (IL-6 reduction by 70%-90%) might not be a little too much.
The excellent papers by Ohm and Trding are more than enough to illustrate the problem shall the congressman or his/her aides decide to read more.
The links below are "general" articles on this subject in simple terms not necessary pitching Leronlimab but stressing the point of the storm in the outcomes.
____________________________________________________________________
Here’s a playbook for stopping deadly cytokine storm syndrome: Explains in simple terms what is a cytokine storm and proposed some other drugs, but brings the point home of why is so important.
https://www.uab.edu/reporter/know-more/public...m-syndrome
This explains in general terms Clinical Features of Hospitalized COVID-19 Infected Individuals & Their Relationship to Cytokine Storm Syndrome Criteria
https://www.the-rheumatologist.org/article/do...ine-storm/
COVID-19: consider cytokine storm syndromes and immunosuppression
https://www.thelancet.com/journals/lancet/art...0/fulltext
Accumulating evidence suggests that a subgroup of patients with severe COVID-19 might have a cytokine storm syndrome. We recommend identification and treatment of hyperinflammation using existing, approved therapies with proven safety profiles to address the immediate need to reduce the rising mortality. This article relates IL-6 reduction with the 30-day prediction of mortality (remember that we are reducing this in 70%-90%)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4073574/
Great initiative !!!
The best is to explain in lay terms what causes death in COVID patients and why Leronlimab has proven to be very effective.
The Cytokine storm argument is very strong.
Also, it should be related to the measurements that have already demonstrated, a congressman will be more prone to understand that patients have been taken out of ventilators and this does not happen often and that measurements (blood work) confirm that it works (IL-6 reduction by 70%-90%) might not be a little too much.
The excellent papers by Ohm and Trding are more than enough to illustrate the problem shall the congressman or his/her aides decide to read more.
The links below are "general" articles on this subject in simple terms not necessary pitching Leronlimab but stressing the point of the storm in the outcomes.
____________________________________________________________________
Here’s a playbook for stopping deadly cytokine storm syndrome: Explains in simple terms what is a cytokine storm and proposed some other drugs, but brings the point home of why is so important.
https://www.uab.edu/reporter/know-more/public...m-syndrome
This explains in general terms Clinical Features of Hospitalized COVID-19 Infected Individuals & Their Relationship to Cytokine Storm Syndrome Criteria
https://www.the-rheumatologist.org/article/do...ine-storm/
COVID-19: consider cytokine storm syndromes and immunosuppression
https://www.thelancet.com/journals/lancet/art...0/fulltext
Accumulating evidence suggests that a subgroup of patients with severe COVID-19 might have a cytokine storm syndrome. We recommend identification and treatment of hyperinflammation using existing, approved therapies with proven safety profiles to address the immediate need to reduce the rising mortality. This article relates IL-6 reduction with the 30-day prediction of mortality (remember that we are reducing this in 70%-90%)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4073574/
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