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Posted On: 04/03/2020 1:43:44 PM
Post# of 36549
Important Question - Please Help me
At this moment, at what stage are we in the development of the vaccine against COVID-19?
I want to knoW!
From Generex web site:
Rapid Path to SARS-COV-2 Vaccine: 3 Months to Human Vaccination
1. Generex & Epivax have identified SARS-COV-2 amino acid peptides for epitope evaluation
2. Synthesize 2019-nCoV epitope peptides for screening (standard peptide chemistry – 11 - 15 amino acids)
3. Screen common HLA-DR alleles in vitro vs SARS-COV-2 sequences
4. Test chemical linkers with for best fit for Ii-Key (LRMK) hybrid vaccine – optimize for immunogenicity
5. Select Ii-Key Hybrid/2019-nCoV peptides for vaccine evaluation
6. Collect blood samples & isolate PBMCs from 2019-nCoV infected & recovered individuals
7. Test Ii-Key/ SARS-COV-2 hybrid peptide vaccines vs. PBMcs
8. Conduct Elispot analysis to test for IFN-γ expression indicating CD-4 T-cell activation
9. Select active Ii-Key/ SARS-COV-2 hybrid peptide vaccines for human clinical testing
10. Conduct Clinical Trial with Lead Ii-Key/SARS-COV-2 Peptides • Evaluate safety & immunogenicity (DTH Assay)
11. Select peptides for Multi-valent Ii-Key/ SARS-COV-2 Peptide Vaccine
12. Commercial Manufacturing & Distribution in 5 to 9 months
At this moment, at what stage are we in the development of the vaccine against COVID-19?
I want to knoW!
From Generex web site:
Rapid Path to SARS-COV-2 Vaccine: 3 Months to Human Vaccination
1. Generex & Epivax have identified SARS-COV-2 amino acid peptides for epitope evaluation
2. Synthesize 2019-nCoV epitope peptides for screening (standard peptide chemistry – 11 - 15 amino acids)
3. Screen common HLA-DR alleles in vitro vs SARS-COV-2 sequences
4. Test chemical linkers with for best fit for Ii-Key (LRMK) hybrid vaccine – optimize for immunogenicity
5. Select Ii-Key Hybrid/2019-nCoV peptides for vaccine evaluation
6. Collect blood samples & isolate PBMCs from 2019-nCoV infected & recovered individuals
7. Test Ii-Key/ SARS-COV-2 hybrid peptide vaccines vs. PBMcs
8. Conduct Elispot analysis to test for IFN-γ expression indicating CD-4 T-cell activation
9. Select active Ii-Key/ SARS-COV-2 hybrid peptide vaccines for human clinical testing
10. Conduct Clinical Trial with Lead Ii-Key/SARS-COV-2 Peptides • Evaluate safety & immunogenicity (DTH Assay)
11. Select peptides for Multi-valent Ii-Key/ SARS-COV-2 Peptide Vaccine
12. Commercial Manufacturing & Distribution in 5 to 9 months
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