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Posted On: 04/02/2020 8:30:56 AM
Post# of 154275
misiu, so we know 2 of the first four came off Ventilator. Being these were all Emergency IND patients, its plausible from the first 4 the treating doctor believed improvement was great enough to immediately get 6 more injected.
Yes it would be good to get additional specifics from all the patients but I am sure FDA has informed us of what statements can and can not be made public at this time. Trend to normalization of the CD4/CD8 ratio tells us Immune system is getting back to normal.
From Bruce Patterson:
We continue to see increases in the profoundly decreased CD8 T-lymphocyte percentages by Day 3, normalization of CD4/CD8 ratios, and resolving cytokine production including reduced IL-6 correlating with patient improvement. The current data suggests a trend toward the restoration of immune function and mitigation of the cytokine storm. This is consistent with prior laboratory results in the first four patients treated for COVID-19 with leronlimab.”
Yes it would be good to get additional specifics from all the patients but I am sure FDA has informed us of what statements can and can not be made public at this time. Trend to normalization of the CD4/CD8 ratio tells us Immune system is getting back to normal.
From Bruce Patterson:
We continue to see increases in the profoundly decreased CD8 T-lymphocyte percentages by Day 3, normalization of CD4/CD8 ratios, and resolving cytokine production including reduced IL-6 correlating with patient improvement. The current data suggests a trend toward the restoration of immune function and mitigation of the cytokine storm. This is consistent with prior laboratory results in the first four patients treated for COVID-19 with leronlimab.”
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