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Posted On: 02/28/2020 4:08:03 AM
Post# of 154140
Coronavirus Treatment (COVID-19) and Cytodyn's drug Leronlimab
There has been debate about whether leronlimab will be an effective treatment for the coronavirus COVID-19. Here is the science behind it's efficacy as a treatment.
Leronlimab has two paths to treatment, the first being reduction of inflammation which is almost always the primary cause of death and the second is boosting the immune system to help the body's own immune system to fight off the virus directly
It's role as an anti-inflammatory -
The infection causes inflammation in the air sacs in your lungs.The air sacs fill with fluid or pus, in severe cases this leads to death.
There has been debate about whether leronlimab will be an effective treatment for the coronavirus COVID-19. Here is the science behind it's efficacy as a treatment.
Leronlimab has two paths to treatment, the first being reduction of inflammation which is almost always the primary cause of death and the second is boosting the immune system to help the body's own immune system to fight off the virus directly
It's role as an anti-inflammatory -
Quote:https://www.medscape.com/viewarticle/925681
In serious cases of infection, the COVID-19 virus invades the cells that line the respiratory tract and lungs and enters the mucus, causing pneumonia. Severe lung damage from pneumonia can result in acute respiratory distress syndrome (ARDS), which in turn can cause septic shock.
The infection causes inflammation in the air sacs in your lungs.The air sacs fill with fluid or pus, in severe cases this leads to death.
Quote:
IL-13 is a potent stimulator of eosinophil-, lymphocyte-, and macrophage-rich inflammation, mucus metaplasia, tissue fibrosis, and parenchymal remodeling . They also demonstrated that, in the lung, IL-13 induces asthma-like airway hyperresponsiveness on methacholine challenge. In accord with these findings, IL-13 dysregulation has been documented and is felt to play an important role in the pathogenesis of a variety of diseases including asthma, idiopathic pulmonary fibrosis, hepatic fibrosis, fungal pneumonitis, viral pneumonia, nodular-sclerosing Hodgkin’s disease, and chronic obstructive pulmonary disease.
CCR5 neutralization or a deficiency of CCR5 significantly decreases IL13-induced inflammation, alveolar remodeling, structural and inflammatory cell apoptosis, and respiratory failure and death. Lastly, they demonstrate that IL-13 stimulates the production of select chemokines, MMPs, and cell death regulators and activates pulmonary caspases via CCR5-dependent mechanisms.
https://www.jimmunol.org/content/jimmunol/176...8.full.pdf
It's role as an immune booster -
Leronlimab boosts the immune system through macrophage differentiation resulting in an increase in natural killer T-cells.
Quote:
The eutopic expression of CCR5 activates calcium signaling and thereby augments regulatory T cell (Treg) differentiation
https://cancerres.aacrjournals.org/content/79/19/4801
Quote:
Strong calcium signaling in T cells has been associated with secretion of Th1 cytokines, whereas defective calcium flux is associated with anergy and altered cytokine production
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2581981/
Th1 cytokines increase cytotoxic lymphocytes (CTL & NKT cells) that are responsible for the cell-mediated immune response against viruses and tumor cells.
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