Heck, it doesn't have to be much.....COCP announced a licensing agreement with Kansas State University and it went from 49c to 2.67. They of course announced a 11M dollar offering the next day.

Quote:

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COCRYSTAL PHARMA, INC. (NASDAQ: COCP) (“Cocrystal” or the “Company”), a clinical stage biotechnology company discovering and developing novel antiviral therapeutics, today announced that it has entered into a license agreement with Kansas State University Research Foundation (“KSURF”) to further develop certain proprietary broad-spectrum antiviral compounds for the treatment of Norovirus and Coronavirus infections.

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