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Posted On: 02/18/2020 11:34:17 AM
Post# of 36568
NGIO/AE Sars preclinical working related to the Coronavirus.
Hi Winger
“ Example 29. li-Key/SARS MHC class Il epitope hybrids
[00429] Prediction of Epitopes. SARS coronavirus encodes two replicases, a spike protein, and a N protein and other proteins (genbank AY278488, AY278554, AY274119, AY278741). The 30k virus genomes of different sources are highly homologous, indicating SARS coronavirus to be relatively stable. The "Beijing" coronavirus sequence AY278488 is taken as a prototypic model. One putative replicase (ORF-1 D), spike protein, and N protein have a high frequency of high- scoring HLA-DR-restricted epitopes upon examination with the Raghava program (http://www.imtech.res.in/raghava/propred/).40 SARS epitopes were identified and corresponding li-Key hybrids were synthesized. In order to test the possibility that more HLA-DR-restricted SARS epitopes are present in both S and N proteins, overlapping peptides (32 amino acids) were also synthesized for testing, according to the following principles.”
From a patent- 2006
https://patents.google.com/patent/WO2006076410A2/en
Hi Winger
“ Example 29. li-Key/SARS MHC class Il epitope hybrids
[00429] Prediction of Epitopes. SARS coronavirus encodes two replicases, a spike protein, and a N protein and other proteins (genbank AY278488, AY278554, AY274119, AY278741). The 30k virus genomes of different sources are highly homologous, indicating SARS coronavirus to be relatively stable. The "Beijing" coronavirus sequence AY278488 is taken as a prototypic model. One putative replicase (ORF-1 D), spike protein, and N protein have a high frequency of high- scoring HLA-DR-restricted epitopes upon examination with the Raghava program (http://www.imtech.res.in/raghava/propred/).40 SARS epitopes were identified and corresponding li-Key hybrids were synthesized. In order to test the possibility that more HLA-DR-restricted SARS epitopes are present in both S and N proteins, overlapping peptides (32 amino acids) were also synthesized for testing, according to the following principles.”
From a patent- 2006
https://patents.google.com/patent/WO2006076410A2/en
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