"Having no systemic absorption will mean the future trials will be much less likely to have systemic complications and the trials will likely have less testing of future study patients for systemic complications which should stream line future studies".
BOOM Game on.

My thinking also is with no systemic absorption oral B should be a safe option for anyone no matter their weakened condition or what other medication they may be taking as there would no fear of drug interaction and maybe even safe for breast feeding mothers who suffer UC.