(Total Views: 500)
Posted On: 01/29/2020 8:10:41 AM
Post# of 72446
Would love to read and learn from responses made by those who fully understand the science, which I do not. If this got picked up by mainstream media things could get really interesting in a hurry IMHO. Go IPIX!!!
georgejjl Tuesday, 01/28/20 08:57:30 PM
Re: None 0
Post # of 280776
Rhesus theta-defensin prevents death in a mouse model of severe acute respiratory syndrome coronavirus pulmonary disease.
Wohlford-Lenane CL1, Meyerholz DK, Perlman S, Zhou H, Tran D, Selsted ME, McCray PB Jr.
Author information
1
Department of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA.
Abstract
We evaluated the efficacy of rhesus theta-defensin 1 (RTD-1), a novel cyclic antimicrobial peptide, as a prophylactic antiviral in a mouse model of severe acute respiratory syndrome (SARS) coronavirus (CoV) lung disease. BALB/c mice exposed to a mouse-adapted strain of SARS-CoV demonstrated 100% survival and modest reductions in lung pathology without reductions in virus titer when treated with two intranasal doses of RTD-1, while mortality in untreated mice was approximately 75%. RTD-1-treated, SARS-CoV-infected mice displayed altered lung tissue cytokine responses 2 and 4 days postinfection compared to those of untreated animals, suggesting that one possible mechanism of action for RTD-1 is immunomodulatory.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2772759/
Defensins are small cysteine-rich cationic proteins across cellular life, including vertebrate[1] and invertebrate[2] animals, plants,[3][4] and fungi.[5] They have also been reported in plants. They are, and function as, host defense peptides. They are active against bacteria, fungi and many enveloped and nonenveloped viruses.
https://en.wikipedia.org/wiki/Defensin
Brilacidin is now available as an oral pill formulation.
Good luck and GOD bless,
georgejjl Tuesday, 01/28/20 08:57:30 PM
Re: None 0
Post # of 280776
Rhesus theta-defensin prevents death in a mouse model of severe acute respiratory syndrome coronavirus pulmonary disease.
Wohlford-Lenane CL1, Meyerholz DK, Perlman S, Zhou H, Tran D, Selsted ME, McCray PB Jr.
Author information
1
Department of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA.
Abstract
We evaluated the efficacy of rhesus theta-defensin 1 (RTD-1), a novel cyclic antimicrobial peptide, as a prophylactic antiviral in a mouse model of severe acute respiratory syndrome (SARS) coronavirus (CoV) lung disease. BALB/c mice exposed to a mouse-adapted strain of SARS-CoV demonstrated 100% survival and modest reductions in lung pathology without reductions in virus titer when treated with two intranasal doses of RTD-1, while mortality in untreated mice was approximately 75%. RTD-1-treated, SARS-CoV-infected mice displayed altered lung tissue cytokine responses 2 and 4 days postinfection compared to those of untreated animals, suggesting that one possible mechanism of action for RTD-1 is immunomodulatory.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2772759/
Defensins are small cysteine-rich cationic proteins across cellular life, including vertebrate[1] and invertebrate[2] animals, plants,[3][4] and fungi.[5] They have also been reported in plants. They are, and function as, host defense peptides. They are active against bacteria, fungi and many enveloped and nonenveloped viruses.
https://en.wikipedia.org/wiki/Defensin
Brilacidin is now available as an oral pill formulation.
Good luck and GOD bless,
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