People need to realize that milligrams of drug measurements are not measures of potency across all drug treatments.
500mg of Tylenol is not the same as the effectiveness as 500mg of Motrin.500mg of cyanide vs 500mg of rat poison are 2 different comps as well.5mg of one dug will kill you whereas 1000mg of another drug will help you.

The dosing in the current trials are based on the efficacy from the previous trials.The strength (milligrams)of the medication is based on prior experience and data from previous trials.