“It appears most of the viral load breakouts in patients in the 700 mg dose arm are due to an event such as a flu or vaccination that cause the number of T-cells to rise. With additional T-cells, numerous additional CCR5 co-receptors must be covered by PRO 140 to maintain suppressed HIV viral load. Among the patients enrolled thus far in the 700 mg dose arm, only two viral load breakouts have been noted, one patient received a vaccination and the second patient’s breakout is still being investigated,” added Dr. Lalezari.

Over 800 patients on Leronlimab back a couple of years and no serious side effects. Of course Leronlimab is much better than Vicriviroc and Maraviroc which have bad side effects and are not as effective, nevertheless Maraviroc is still used today.