On the OTCQB Best Market, the middle tier of OTC Markets, trading volume in CytoDyn Inc. (OTCQX:CYDY), a Canadian biotech company, rose 385% in December, making it the most active security traded on the market apart from Fannie Mae and Freddie Mac. The volume increase coincided with a 293% rally for the stock in December, as shares rose from $0.30 to a high of $1.18.