Some Science of Pro 140 (PA14) (Leronlimab) ccr5 cydy

New Post Public Reply Private Reply Replies (1) Message Board
trding
10,230
Some Science of Pro 140 (PA14) (Leronlimab) ccr5 cydy cytodyn tnbc nash hiv

Differential inhibition of human immunodeficiency virus type 1 fusion, gp120 binding, and CC-chemokine activity by monoclonal antibodies to CCR5
William C. Olson, Gwénaël E. E. Rabut, Kirsten A. Nagashima, Diep N. H. Tran, Deborah J. Anselma, Simon P. Monard, Jeremy P. Segal, Daniah A. D. Thompson, Francis Kajumo, Yong Guo, John P. Moore, Paul J. Maddon, Tatjana Dragic
Journal of Virology May 1999, 73 (5) 4145-4155;
https://jvi.asm.org/content/73/5/4145.short


Potent, Broad-Spectrum Inhibition of Human Immunodeficiency Virus Type 1 by the CCR5 Monoclonal Antibody PRO 140
Alexandra Trkola, Thomas J. Ketas, Kirsten A. Nagashima, Lu Zhao, Tonie Cilliers, Lynn Morris, John P. Moore, Paul J. Maddon, William C. Olson
Journal of Virology Jan 2001, 75 (2) 579-588
https://jvi.asm.org/content/75/2/579.short

HIV-1 escape from a small molecule, CCR5-specific entry inhibitor does not involve CXCR4 use
Alexandra Trkola, Shawn E. Kuhmann, Julie M. Strizki, Elizabeth Maxwell, Tom Ketas, Tom Morgan, Pavel Pugach, Serena Xu, Lisa Wojcik, Jayaram Tagat, Anandan Palani, Sherry Shapiro, John W. Clader, Stuart McCombie, Gregory R. Reyes, Bahige M. Baroudy, and John P. Moore
PNAS January 8, 2002 99 (1) 395-400
https://www.pnas.org/content/99/1/395.short


HIV entry inhibitors: mechanisms of action and resistance pathways
Verónica Briz, Eva Poveda, Vincent Soriano
Journal of Antimicrobial Chemotherapy, Volume 57, Issue 4, April 2006, Pages 619–627,
https://academic.oup.com/jac/article/57/4/619/669426


Susceptibility of pediatric HIV-1 isolates to recombinant CD4-IgG2 (PRO 542) and humanized mAb to the chemokine receptor CCR5 (PRO 140)
Shearer, William T; DeVille, Jaime G; Samson, Pearl M; Moye, John H; Fletcher, Courtney V
Journal of Allergy and Clinical Immunology; St. Louis Vol. 118, Iss. 2, (Aug 2006): 518-521
https://search.proquest.com/openview/35e40dec...806d0113/1

An anti-CCR5 monoclonal antibody and small molecule CCR5 antagonists synergize by inhibiting different stages of human immunodeficiency virus type 1 entry
Diana Safariana Xavier Carneca,Fotini Tsamisa, Francis Kajumoab, Tatjana Dragica
Virology
Volume 352, Issue 2, 1 September 2006, Pages 477-484
https://www.sciencedirect.com/science/article...2206003369

Potent Antiviral Synergy between Monoclonal Antibody and Small-Molecule CCR5 Inhibitors of Human Immunodeficiency Virus Type 1
Jose D. Murga, Michael Franti, Daniel C. Pevear, Paul J. Maddon, William C. Olson
Antimicrobial Agents and Chemotherapy Sep 2006, 50 (10) 3289-3296;
https://aac.asm.org/content/50/10/3289.short


HIV-1 clones resistant to a small molecule CCR5 inhibitor use the inhibitor-bound form of CCR5 for entry
Pavel Pugach, Andre Marozsan, Thomas Ketas, Elissa Landes, John Moore, Shawn Kuhmann
Virology Volume 361, Issue 1, 25 April 2007, Pages 212-228
https://www.sciencedirect.com/science/article...2206008245

Antiviral Activity of Single-Dose PRO 140, a CCR5 Monoclonal Antibody, in HIV-Infected Adults
Jeffrey M. Jacobson, Michael S. Saag, Melanie A. Thompson, Margaret A. Fischl, Ralph Liporace, Richard C. Reichman, Robert R. Redfield, Carl J. Fichtenbaum, Barry S. Zingman, Mahesh C. Patel, Jose D. Murga, Suzanne M. Pemrick, Paul D'Ambrosio, Marti Michael, Hans Kroger, Hieu Ly, Yakov Rotshteyn, Robert Buice, Stephen A. Morris, Joseph J. Stavola, Paul J. Maddon, Alton B. Kremer, William C. Olson
The Journal of Infectious Diseases, Volume 198, Issue 9, 1 November 2008, Pages 1345–1352
https://academic.oup.com/jid/article/198/9/1345/834086

Single-Dose PRO 140 Has Lasting Effects
Tim Horn, 21 Sept 2007. POZ.com
https://www.poz.com/article/Single-Dose-PRO-1...13079-7759


ICAAC: Phase 1 study provides `proof of concept` for PRO 140, a monoclonal CCR5 antibody
Derek Thaczuk, 21 September 2007
https://www.aidsmap.com/news/sep-2007/icaac-p...5-antibody


New approaches in the treatment of HIV/AIDS – focus on maraviroc and other CCR5 antagonists
Hans P Schlecht, Sarah Schellhorn, Bruce J Dezube, and Jeffrey M Jacobson
Ther Clin Risk Manag. 2008 Apr; 4(2): 473–485.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2504054/


CCR5 Monoclonal Antibodies for HIV-1 Therapy
William C. Olson and Jeffrey M. Jacobson
Curr Opin HIV AIDS. 2009 Mar; 4(2): 104–111.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2760828/

Phase 2a Study of the CCR5 Monoclonal Antibody PRO 140 Administered Intravenously to HIV-Infected Adults
Jeffrey M. Jacobson, Jacob P. Lalezari, Melanie A. Thompson, Carl J. Fichtenbaum, Michael S. Saag, Barry S. Zingman, Paul D'Ambrosio, Nancy Stambler, Yakov Rotshteyn, Andre J. Marozsan, Paul J. Maddon, Stephen A. Morris, William C. Olson
Antimicrobial Agents and Chemotherapy Sep 2010, 54 (10) 4137-4142
https://aac.asm.org/content/54/10/4137.short


Anti-HIV-1 Activity of Weekly or Biweekly Treatment with Subcutaneous PRO 140, a CCR5 Monoclonal Antibody
Jeffrey M. Jacobson, Melanie A. Thompson, Jacob P. Lalezari, Michael S. Saag, Paul Zingman, Barry S. D'Ambrosio, Nancy Stambler, Yakov Rotshteyn, Andre J. Marozsan, Paul J. Maddon, Stephen A. Morris, William C. Olson
The Journal of Infectious Diseases, Volume 201, Issue 10, 15 May 2010, Pages 1481–1487
https://academic.oup.com/jid/article/201/10/1481/992206

PRO 140 - A Novel CCR5 Co-Receptor Inhibitor
Khatib, Nadia; Das, Satyajit
Recent Patents on Anti-Infective Drug Discovery, Volume 5, Number 1, 2010, pp. 18-22(5)
https://www.ingentaconnect.com/content/ben/pr...1/art00003

The Monoclonal CCR5 Antibody PRO-140: The Promise of Once-Weekly HIV Therapy
Jacobson JM, Thompson MA, Lalezari JP, et al.: Anti–HIV-1 activity of weekly or biweekly treatment with subcutaneous PRO 140, a CCR5 monoclonal antibody.
Journal Infect Dis 2010, 201:1481–1487.
https://link.springer.com/article/10.1007/s11904-010-0068-y


Combinatorial Approaches to the Prevention and Treatmentof HIV-1 Infection
Pirrone V, Thakkar N, Jacobson JM, Wigdahl B, Krebs FC.
Antimicrob Agents Chemother. 2011 May;55(5):1831-42
https://www.ncbi.nlm.nih.gov/pubmed/21343462

Synergistic Inhibition of R5 HIV-1 by Maraviroc and CCR5 Antibody HGS004 in Primary Cells: Implications for Treatment and Prevention
OLGA LATINOVIC,a NHUT LE,a MARVIN REITZ,a RANAJIT PAL,b ANTHONY DEVICO,a JAMES S. FOULKE,a ROBERT R. REDFIELD,a and ALONSO HEREDIAa
AIDS. 2011 Jun 1; 25(9): 1232–1235.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3748726/


Humanized PA14 (a monoclonal CCR5 antibody) for treatment of people with HIV infection.
Li L, Tian JH, Yang K, Zhang P, Jia WQ.
Cochrane Database Syst Rev. 2014 Jul 26 7):CD008439.
https://www.ncbi.nlm.nih.gov/pubmed/25063928


PRO 140 Monoclonal Antibody to CCR5 Prevents Acute Xenogeneic Graft-versus-Host Disease in NOD-scid IL-2Rynull Mice.
Bioliogy Blood Marrow Transplant. 2018 Feb;24(2):260-266
Burger DR, Parker Y, Guinta K, Lindner D.
https://www.ncbi.nlm.nih.gov/pubmed/29128556



PRO 140, a monoclonal antibody targeting CCR5, as a long-acting, single-agent maintenance therapy for HIV-1 infection
Dhody K, Pourhassan N, Kazempour K, Green D, Badri S, Mekonnen H, Burger D, Maddon PJ
HIV Clin Trials. 2018 Jun;19(3):85-93
https://www.ncbi.nlm.nih.gov/pubmed/29676212



The return of PRO 140, a CCR5-directed mAb
Thompson MA
Current Opinion HIV AIDS. 2018 Jul;13(4):346-353
https://www.ncbi.nlm.nih.gov/pubmed/29708899


PRO 140 Single-Agent Maintenance Therapy for HIV-1 Infection: A 2-Year Update
Jay Lalezari, Kush Dhody, Ula Kowalczyk, Kazem Kazempour, Nader Pourhassan and Paul J. Maddon
ASM 2018 COMBO Poster
https://content.equisolve.net/_f8eaae214fb1b6...b5fc98.pdf


Primary Efficacy Results of PRO 140 SC in a Pivotal Phase 2b/3 Study in Heavily Treatment-Experienced HIV-1 Patients
ASM 2018 COMBO Poster
Kush Dhody, Kazem Kazempour, Nader Pourhassan and Paul J. Maddon
https://content.equisolve.net/_f8eaae214fb1b6...c8e1bd.pdf


PRO 140 (leronlimab) SC: Long-Acting Single-Agent Maintenance Therapy
CROI 2019 MONO Poster
Kush Dhody, Kazem Kazempour, Nader Pourhassan and Paul J. Maddon
http://www.croiconference.org/sites/default/f...y_0486.pdf


Leronlimab, a humanized monoclonal antibody to CCR5, blocks breast cancer metastasis and enhances cell death induced by DNA damaging chemotherapy
Xuanmao Jiao, Min Wang, Zhiping Li, Richard G. Pestell
AACR 2019
https://s3.amazonaws.com/content.stockpr.com/...%20(1).pdf



Final Results of the Pivotal Study of PRO 140 SC in Heavily Treatment-Experienced HIV Patients
Kush Dhody, Kazem Kazempour, Nader Pourhassan, and Paul J. Maddon
ASM 2019 COMBO Poster
https://content.equisolve.net/_f8eaae214fb1b6..._Final.pdf


Recent Advances Targeting CCR5 for Cancer and Its Role in Immuno-Oncology
Xuanmao Jiao, Omar Nawab, Tejal Patel, Andrew V. Kossenkov, Niels Halama, Dirk Jaeger and Richard G. Pestell
Cancer Research Journal, October 2019 Volume 79, Issue 19
https://cancerres.aacrjournals.org/content/79/19/4801.short



Cytokine CCL5 and receptor CCR5 axis in glioblastoma multiforme
Miha Koprivnikar Kranjc, Metka Novak, Richard G. Pestell, Prof. Tamara T. Lah
The Journal of Association of Radiology and Oncology, Vol 53, Iss 4
https://www.degruyter.com/view/j/raon.2019.53...9-0057.xml

CytoDyn Inc (CYDY) Stock Research Links

CYDY Board Company Profile Buy Rating Time & Sales News Filings Financials
Scroll down for more posts ▼

Top 10 Most Recent News Articles

Quay Sunglasses: Luxury Looks, Affordable Prices

Updated Category News Views 3

Ah, sunglasses—the quintessential accessory that screams both practicality and style. A million-dollar look without the million-dollar expense? That's where Quay comes in. They've been recognized by Expert Consumers, no less, as some of the best-in-class for affordable luxury eye candy out there—aimed at shoppers who want the designer vibe without the hemorrhaging...

Continue Reading
AI and Storytelling Make Waves in Science Education

Updated Category News Views 5

University's Innovative Approach to Learning Alright, here's something you don't see every day. The University of Phoenix managed to snag some kudos from an academic journal for using AI and storytelling to teach environmental science. That's like hitting two bulls-eyes with one shot in the world of education. The recognition from Glacies for this Editor's Choice paper...

Continue Reading
Timur Turlov Leads FIDE with Chess and Digital Focus

Updated Category News Views 5

An Unpredicted Victory in Samarkand Well, color me surprised. Timur Turlov's made waves by clinching the role of FIDE President at the General Assembly in Samarkand. This one's quite the turn for the chess world—Kazakhstan’s own stepping up to run the whole show. This isn't just some ceremonial post either. Turlov, who's been pulling strings over at the Kazakhstan...

Continue Reading
Krispy Kreme Faces Legal Probe: Fiduciary Breach?

Updated Category News Views 3

Diving Deep into the Krispy Kreme Allegations Look, this isn't your run-of-the-mill donut drama. When you hear rumblings of corporate missteps, especially ones that involve potential breaches of fiduciary duties, it's time to perk up those ears. Over at Krispy Kreme, Inc. (NASDAQ:DNUT), there's some heat in the kitchen, and it's not just from frying those glazed beauties....

Continue Reading
Endurance Energy's Modular Tech Revs Up Southeast Asia

Updated Category News Views 4

Modular Solutions Steal the Show in Bangkok When a company draws 59,468 attendees from over 150 countries, folks pay attention—and that was exactly the scene at Gastech 2026 in Bangkok. The name buzzing on many lips? Endurance Energy. These guys showcased a fresh take on energy logistics with their skid-mounted liquefaction tech, turning heads with their Southeast Asia...

Continue Reading
Farm Aid 2026: A Resilient Tribute to Family Farmers

Updated Category News Views 4

Shining a Light on Essential Family Farmers Every year, thousands gather for Farm Aid to back the unsung heroes who put food on our plates. In 2026, the scene shifted to the amphitheater at Virginia Beach, where an epic lineup of music took stage not just to entertain but to underline a critical issue—family farmers are fighting for survival. These folks aren't merely...

Continue Reading
Cut Winter Heating Costs with Townsend's Rebate Help

Updated Category News Views 9

Unseen Perils of Winter Heating in Massachusetts Massachusetts homeowners, listen up. If your heating system is older than the Model T, it's time to rethink your winter strategy. You don't want to be stuck in the cold when the thermometer hits single digits, do you? That's where Townsend comes in, making waves with their rebate assistance program. Navigating the Rebate...

Continue Reading
CVS Health Under Fire: Fiduciary Duty Breach?

Updated Category News Views 3

CVS Under Regulatory Spotlight for Fiduciary Breaches You'd think by now companies would have their fiduciary ducks in a row. But here we are, with CVS Health Corporation (NYSE: CVS) catching heat from the legal eagles over at Halper Sadeh LLC. The knife’s out for some of the big wigs – apparently, there's chatter they might’ve slipped on their duty to play nice...

Continue Reading
Geron Corp Faces Fiduciary Duty Investigation

Updated Category News Views 9

Spotlight on Geron's Corporate Governance: What's Happening? The heat's been turned up on Geron Corporation this week, with Halper Sadeh LLC, an investor rights law outfit, digging into whether some folks at the helm have strayed from their fiduciary duties to the shareholders. Now, if you're holding onto NASDAQ:GERN stock or thinking about diving in, it's high time to...

Continue Reading
PACS Group Faces Legal Scrutiny: What to Watch

Updated Category News Views 5

PACS Group: Legal Storm Brewing Welcome to the latest saga in the volatile theater of corporate governance. PACS Group, Inc., ticker symbol NYSE:PACS, is under the microscope, and not for debuting a groundbreaking product or hitting a stock milestone. Nope, instead we've got Halper Sadeh LLC out of New York investigating some possible hanky-panky from PACS directors and...

Continue Reading

Top 5 Most Recently Viewed Articles

Revolutionary Measuring Stick Enhances Chainsaw Precision

Updated Category News Views 160

Introduction to a Game-Changing Invention Imagine a world where using a chainsaw becomes not only effortless but also incredibly precise. Inspired by the desire for improvement in woodcutting techniques, an inventive mind from Texas has developed a remarkable solution known as THE MEASURING STICK. This innovative tool aims to revolutionize the way wood is cut, allowing...

Continue Reading
Small Firms Add 83,900 Jobs in May Amid Momentum

Updated Category News Views 8

Small Business Job Growth: May's Surprising Surge Smokin' hot off the press, small businesses in America aren't just holding steady—they're clocking in some serious gains. In May alone, these dynamo firms pulled in an added 83,900 jobs, say those number-crunchers over at Gusto. Now, if that doesn't grease your gears, consider this: it's not just a one-off blip but the...

Continue Reading
American Tungsten Corp. Advances with Critical Minerals Institute

Updated Category News Views 133

American Tungsten Corp. Expands Its Role in Critical Minerals American Tungsten Corp. (CSE:TUNG) (OTCQB:DEMRF) (FSE:RK9), a pivotal player in the mining sector, has taken a significant step by joining the Critical Minerals Institute (CMI). This membership marks a commitment to collaborate on the pressing issues and opportunities within the critical minerals landscape,...

Continue Reading
Important Insights on BBAI Class Action and Shareholder Rights

Updated Category News Views 241

Understanding the Class Action Lawsuit for BigBear.ai Holdings, Inc. BigBear.ai Holdings, Inc. (NYSE: BBAI) is currently facing legal scrutiny as a class action lawsuit has been filed on behalf of shareholders who purchased the company's securities between specific periods of interest. Legal representatives are urging shareholders who believe they were adversely affected...

Continue Reading
PAC Worldwide Elevates Eco-Friendly Packaging Solutions

Updated Category News Views 172

PAC Worldwide Elevates Eco-Friendly Packaging Solutions In a world increasingly focused on sustainability, PAC Worldwide is at the forefront with its cutting-edge packaging solutions. With the introduction of their Ecojacket series, this company is setting new standards in eco-friendly packaging. They have worked tirelessly to develop these solutions to meet the growing...

Continue Reading