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Posted On: 11/13/2019 9:30:17 AM
Post# of 151008

Re: DoubleBagger24 #10880
No problem. I found the mono p2 paper, it didn't specify the reason for the difference, just there was a difference between the IC90 values at baseline for the responder group and rebound group. The higher density though would explain why the rebound group required more PRO 140 at baseline.
Quote:
In addition, no changes in HIV-1 co-receptor tropism following virologic rebound were seen. PhenoSense® Entry results for PRO 140, maraviroc, and AMD3100 showed no significant change in post-treatment IC 50 and IC 90, compared with baseline results in virologic rebound patients. However, there was a noted difference in the IC90 values from virologic rebound (10.8+/−9.28) and non virologic rebound (6.7+/−6.groups on entry analysis indicating that more PRO 140 was required to reach IC90 by the group that was destined to rebound on PRO 140 monotherapy
Quote:
However, an aggregate analysis showed that the participants which experienced virologic rebound had higher IC 90 values for PRO 140 at baseline (10.8 μg/mL) compared to participants without virologic rebound (6.7 μg/mL)


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