(Total Views: 411)
Posted On: 11/02/2019 6:05:35 PM
Post# of 153996
trding, Misiu,
Excellent posts !!! The only probably addition to what you both said (I am not trained in medicine and this is coming only form what I have been reading to understand the process) is that the donors had double copies of a CCR5-delta-32 gene mutation. This is important because the HIV infection process works like this:
"Generally speaking, HIV-1 enters host cells by binding to a CD4 receptor and then interacting with either CCR5, or the CXC chemokine receptor (CXCR4). Having two identical alleles (alternative form of a gene) for a 32-bp deletion (delta32/delta32) confers high resistance against HIV-1 acquisition."
Also, more relevant copy-and paste from articles"
"Experts caution that even if CCR5-delta-32 stem cell transplantation can lead to a functional cure of HIV, this high-risk procedure will not be an option for most people."
"This is not a treatment appropriate for people with HIV who do not have cancer," the Treatment Action Group said in a statement. "The hope is that lessons can be learned to help develop more widely applicable therapeutic approaches for attaining HIV remissions or cures."
"Stem cell transplantation is life-threatening, with a mortality rate of 10 to 25%. Brown nearly died during the process and was left with lasting side-effects. However, this new case adds to the evidence that using gene therapy to delete CCR5 receptors from T cells may be a feasible approach."
Amen, if Dr. Sacha can replicate a SAE's free procedure to mimic this the sky is the limit for PrEP and maybe cure ... Not to mention SP.
Looking forward to reading his coming paper.
Excellent posts !!! The only probably addition to what you both said (I am not trained in medicine and this is coming only form what I have been reading to understand the process) is that the donors had double copies of a CCR5-delta-32 gene mutation. This is important because the HIV infection process works like this:
"Generally speaking, HIV-1 enters host cells by binding to a CD4 receptor and then interacting with either CCR5, or the CXC chemokine receptor (CXCR4). Having two identical alleles (alternative form of a gene) for a 32-bp deletion (delta32/delta32) confers high resistance against HIV-1 acquisition."
Also, more relevant copy-and paste from articles"
"Experts caution that even if CCR5-delta-32 stem cell transplantation can lead to a functional cure of HIV, this high-risk procedure will not be an option for most people."
"This is not a treatment appropriate for people with HIV who do not have cancer," the Treatment Action Group said in a statement. "The hope is that lessons can be learned to help develop more widely applicable therapeutic approaches for attaining HIV remissions or cures."
"Stem cell transplantation is life-threatening, with a mortality rate of 10 to 25%. Brown nearly died during the process and was left with lasting side-effects. However, this new case adds to the evidence that using gene therapy to delete CCR5 receptors from T cells may be a feasible approach."
Amen, if Dr. Sacha can replicate a SAE's free procedure to mimic this the sky is the limit for PrEP and maybe cure ... Not to mention SP.
Looking forward to reading his coming paper.
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