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Posted On: 10/11/2019 2:32:52 AM
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Mesencephalic Astrocyte-Derived Neurotrophic Factor Is Upregulated with Therapeutic Fasting in Humans and Diet Fat Withdrawal in Obese Mice
In summary, increased levels of MANF were observed after therapeutic fasting in humans and after diet intervention in obese mice, suggesting that endogenous MANF may be involved in promoting organismal health. Further studies will elucidate whether this knowledge can be used to design novel therapies. More specifically, it would be interesting to determine if the observed changes in MANF concentrations are directly related to changes in UPR activity, or if MANF is involved in metabolic regulation, possibly in connection to adiponectin.
https://www.nature.com/articles/s41598-019-50841-6
In summary, increased levels of MANF were observed after therapeutic fasting in humans and after diet intervention in obese mice, suggesting that endogenous MANF may be involved in promoting organismal health. Further studies will elucidate whether this knowledge can be used to design novel therapies. More specifically, it would be interesting to determine if the observed changes in MANF concentrations are directly related to changes in UPR activity, or if MANF is involved in metabolic regulation, possibly in connection to adiponectin.
https://www.nature.com/articles/s41598-019-50841-6
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