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Posted On: 10/07/2019 2:50:04 AM
Post# of 148892
Leronlimab downregulates IFN -gamma and therefore limits production of PDL-1. I have not found to what extent it limits PDL-1. If leronlimab is very effective against PDL-1 production, Keytruda may be irrelevant.
https://www.cell.com/cancer-cell/pdf/S1535-61...0102-7.pdf
Quote:
However, while release of IFN-gamma by T lymphocytes (CD8+ T cell in particular) is one of the main mechanisms supporting the tumor environmental upregulation of PD-L1, liver metastasis-infiltrating T cells produce CCL5 but no IFN-gamma
https://www.cell.com/cancer-cell/pdf/S1535-61...0102-7.pdf
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