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Posted On: 08/27/2019 4:59:16 PM
Post# of 154120
Yeah, I will do a little research into it when I get time. Just a quick google search apparently there is research going back 20 years on how to extend the half-life of mAbs. I'm not sure if this is how there are doing it, but brilliant idea from Sacha! That dude is smart.
http://dmd.aspetjournals.org/content/42/11/1890
https://www.ncbi.nlm.nih.gov/pubmed/26018774
Quote:
Binding of mAbs to FcRn and the role of this interaction in protecting mAbs from degradation and extending their biologic half-life is well established (Ghetie et al., 1996; Junghans and Anderson, 1996),
http://dmd.aspetjournals.org/content/42/11/1890
https://www.ncbi.nlm.nih.gov/pubmed/26018774
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