One other item Lalezari said was of interest to me, it is hard to find metastatic patients in the naive setting. I am trying to find the percent of tnbc that are first diagnosed at stage 4. So far I can’t find any statistics on stage breakdown at first diagnoses. I did find the 5 year survival rate is 77% for overall tnbc, but 22% for metastatic, So most of the majority of first diagnosed tnbc patients must be stage 3 or less. Could be the big issue. Also giveb that only 3-5% are usually interested in clinical trials, and you could have a small number of potential patients. That is why they need the big sites on it.

The American Cancer Society report the following 5-year survival rates for breast cancer:

stage 0 to 1 — near 100 percent survival rate
stage 2 — about 93 percent survival rate
stage 3 — 72 percent survival rate
stage 4 (metastatic) — 22 percent survival rate