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Posted On: 08/09/2019 12:38:37 PM
Post# of 145915
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Re: craigakess #5958
Quote:
does anyone know how long it took Leronlimab to register a meaningful drop in HIV viral load, such that the results were reported as being successful?
To add to plavac. With combo, they compared people failing haart, added placabo vs leronlimab, the p-value <.01 after 1 week. To be considered successful, the VL had to drop .5log 10 (or about 67%). A drop of 60% would be considered a failure. I was saying yesterday, if they had ran the placabo vs leronlimab two weeks, it might have been even better results. Pills get 7-14 doses during the first week, with their short half-life, they reach full strength within the first week, but leronlimab with the long half-life and weekly dosing takes a few weeks. Even still great results at the reduced strength after 1 week.
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