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Posted On: 08/09/2019 8:24:45 AM
Post# of 151005
I agree, very hard to catch them all, they are everywhere, and they seem to turn off the cell kill allowing them live a long time, which is why it took so long after many failed attempts to cure a second patient.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362902/
Anatomical HIV reservoirs
After HIV enters the body and local replication occurs at the site of entry, HIV quickly disseminates to the lymph nodes (within days) and later on (within weeks) to the bloodstream [46]. At this point, the virus spreads throughout the entire body as individual virions, by the transport of infected immune cells and by cell-to-cell transmission [20,47]. Indeed HIV-infected cells have been found in the brain (and cerebrospinal fluid), the lungs, kidneys, liver, adipose tissue, in the gastrointestinal tract, the male and female genitourinary systems and bone marrow [20,22]. However, the lymphoid tissues (spleen, thymus, lymph nodes, GALT) are the most important sites of viral replication during active infection, and HIV DNA can still be detected in the lymph nodes after years of cART [22] . Within these organs, HIV is usually found within T cells and macrophages, but also in more organ-specific cell types (such as epithelial cells, microglia, astrocytes and podocytes) [19,20,22]. The contribution of all these anatomical compartments as latent reservoirs is still debated.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362902/
Anatomical HIV reservoirs
After HIV enters the body and local replication occurs at the site of entry, HIV quickly disseminates to the lymph nodes (within days) and later on (within weeks) to the bloodstream [46]. At this point, the virus spreads throughout the entire body as individual virions, by the transport of infected immune cells and by cell-to-cell transmission [20,47]. Indeed HIV-infected cells have been found in the brain (and cerebrospinal fluid), the lungs, kidneys, liver, adipose tissue, in the gastrointestinal tract, the male and female genitourinary systems and bone marrow [20,22]. However, the lymphoid tissues (spleen, thymus, lymph nodes, GALT) are the most important sites of viral replication during active infection, and HIV DNA can still be detected in the lymph nodes after years of cART [22] . Within these organs, HIV is usually found within T cells and macrophages, but also in more organ-specific cell types (such as epithelial cells, microglia, astrocytes and podocytes) [19,20,22]. The contribution of all these anatomical compartments as latent reservoirs is still debated.
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