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Posted On: 08/09/2019 1:19:38 AM
Post# of 148936
Using a patient's own stem cells there is no GvHD.
Even though untrained T-cells might attack reservoir cells I believe that would be unnecessary in HIV. In cancers the residual tumor cells could re-establish themselves unless they are killed off by naive T-cells. With a modified CCR5 receptor the HIV from any erupting reservoir cells would have nowhere to attach to and would die off fairly quickly rather than reproduce.
Quote:
Based on the data that we've gotten and what I've looked at, I think that what purged Brown’s HIV reservoir was this graft-versus-HIV reservoir effect [the donor T cells recognized and killed his HIV-infected cells]. We know in people with blood cancers who receive bone marrow transplants, what puts them in remission is the graft-versus-leukemia effect. The CCR5 mutation probably played a role to some degree, but I think the most important component was the graft-versus-HIV reservoir.
Even though untrained T-cells might attack reservoir cells I believe that would be unnecessary in HIV. In cancers the residual tumor cells could re-establish themselves unless they are killed off by naive T-cells. With a modified CCR5 receptor the HIV from any erupting reservoir cells would have nowhere to attach to and would die off fairly quickly rather than reproduce.
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