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Posted On: 08/05/2019 2:30:19 PM
Post# of 154275
Good overview.
My understanding or interpretation of 1) The GPS effect.
To me it is two parts, though both I guess classify as the gps effect, the seems slightly different
1) CCR5 makes the tumor more aggressive, the ccr5+ cancer cells cluster together in a different way, which enables the cancer cells to be become metastatic.
Here is an agent based paper explaining what I am trying to say, these projections are ccr5+
https://bmcsystbiol.biomedcentral.com/article...017-0445-x
2) Once the cancer cells enter the bloodstream and (and thus become) CTCs, being ccr5+ guides them to the most dangerous and deadly possible sites: brain, bones, organs.
My understanding or interpretation of 1) The GPS effect.
To me it is two parts, though both I guess classify as the gps effect, the seems slightly different
1) CCR5 makes the tumor more aggressive, the ccr5+ cancer cells cluster together in a different way, which enables the cancer cells to be become metastatic.
Here is an agent based paper explaining what I am trying to say, these projections are ccr5+
https://bmcsystbiol.biomedcentral.com/article...017-0445-x
2) Once the cancer cells enter the bloodstream and (and thus become) CTCs, being ccr5+ guides them to the most dangerous and deadly possible sites: brain, bones, organs.
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