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Posted On: 07/18/2019 7:02:02 AM
Post# of 149713
Ccr5 also plays roles with the TAMs
http://cancerdiscovery.aacrjournals.org/content/6/6/571.2
The CCL5 receptor, CCR5, is not typically expressed on primary colorectal tumor cells, but was expressed by metastatic tumor cells. The production of CCL5 by T cells in the microenvironment promoted tumor cell proliferation and invasion, and increased production of matrix metalloproteinases by tumor-associated macrophages (TAM).
http://cancerdiscovery.aacrjournals.org/content/6/6/571.2
The CCL5 receptor, CCR5, is not typically expressed on primary colorectal tumor cells, but was expressed by metastatic tumor cells. The production of CCL5 by T cells in the microenvironment promoted tumor cell proliferation and invasion, and increased production of matrix metalloproteinases by tumor-associated macrophages (TAM).
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