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Posted On: 05/30/2019 5:19:35 PM
Post# of 149820
Yes, probably, I'm looking to see even with multiple drugs how the 98% tumor burden reduction with leronlimab with mTNBC compares.
I found this summary with Herceptin by itself, looks like from this first paper I found they got a tumor volume reduction of 67.4% with breast cancer in animal studies.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4963137/
The Efficacy of Trastuzumab in Animal Models of Breast Cancer: A Systematic Review and Meta-Analysis
I need to make sure tumor burden translates to tumor volume, which seems to on first glance from the definition below.
https://www.cancer.gov/publications/dictionar...mor-burden
tumor burden
Refers to the number of cancer cells, the size of a tumor, or the amount of cancer in the body. Also called tumor load.
I found this summary with Herceptin by itself, looks like from this first paper I found they got a tumor volume reduction of 67.4% with breast cancer in animal studies.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4963137/
The Efficacy of Trastuzumab in Animal Models of Breast Cancer: A Systematic Review and Meta-Analysis
Quote:
Of these, 158 experiments assessed tumour volume as the outcome measure, with 11 reporting animal survival. Trastuzumab treatment was associated with a substantial reduction in tumour growth—with control tumours growing to 3.07 times the volume of treated tumours (95%CI 2.62–3.60). That is, tumour volume in treated animals was reduced by 67.4% (95%CI 61.8% - 72.2%).
I need to make sure tumor burden translates to tumor volume, which seems to on first glance from the definition below.
https://www.cancer.gov/publications/dictionar...mor-burden
tumor burden
Refers to the number of cancer cells, the size of a tumor, or the amount of cancer in the body. Also called tumor load.
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