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Posted On: 05/30/2019 4:12:42 PM
Post# of 149836
Yeah, the standard treatment with most ccr5+ cancers will probably be chemo + leronlimab. I was just talking about mTnbc. I have been searching for mouse models with approved drugs to see if any hit 98% reduction in tumor burden. It is hard to find results like we have announced, but I will continue to look.
I looked up the line they used in colon study listed in the PR.
https://www.atcc.org/en/Products/All/CCL-228.aspx
https://www.sigmaaldrich.com/catalog/product/...;region=US
The patient had Dukes' type B, colorectal adenocarcinoma
The initial cultures contained a mixture of epithelial and bipolar cells, but subsequently epithelial cells predominated. The cells produce CEA.
https://www.cancer.gov/publications/dictionar...tal-cancer
I looked up the line they used in colon study listed in the PR.
Quote:
The SW480 cell line was derived from a patient with colon adenocarcinoma and, like many human cancers, was CCR5-positive.
https://www.atcc.org/en/Products/All/CCL-228.aspx
https://www.sigmaaldrich.com/catalog/product/...;region=US
The patient had Dukes' type B, colorectal adenocarcinoma
The initial cultures contained a mixture of epithelial and bipolar cells, but subsequently epithelial cells predominated. The cells produce CEA.
https://www.cancer.gov/publications/dictionar...tal-cancer
Quote:
Dukes B colorectal cancer
Cancer has spread (1) through the muscle layer of the colon and/or rectal wall to the serosa (outermost layer) of the colon and/or rectal wall; or (2) through the serosa of the colon and/or rectal wall but has not spread to nearby organs; or (3) through the serosa of the colon and/or rectal wall to nearby organs. Also called stage II colorectal cancer.
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