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Posted On: 05/18/2019 6:57:32 AM
Post# of 154011
Ohm. You bring up good points. I don't know much about bone marrow transplants. It may come down to where the hidden HIV reservoirs are located. If they are 100% in the circulating memory CD4 cells which have a half-life of 4 years, then maybe long term leronlimab treatment greater than10 years alone could cure if all these cells eventually die and are replaced by new leronlimab treated cells from bone marrow.
Also if pretreatment for transplant can kill 100% of these cells somehow, then maybe autologous transplant of patients own leronlimab treated bone marrow is possible. I don't know the answer and would defer to others.
One minor point. I believe that cd32 refers to a memory CD4 cell and delta32 is the mutation that prevents CCR 5 virus infection
Also if pretreatment for transplant can kill 100% of these cells somehow, then maybe autologous transplant of patients own leronlimab treated bone marrow is possible. I don't know the answer and would defer to others.
One minor point. I believe that cd32 refers to a memory CD4 cell and delta32 is the mutation that prevents CCR 5 virus infection
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